TIMP-1 and its potential diagnostic and prognostic value in pulmonary diseases

Chinese medical journal pulmonary and critical care medicine Pub Date : 2023-06-01 DOI:10.1016/j.pccm.2023.05.002

Sultan Almuntashiri , Abdullah Alhumaid , Yin Zhu , Yohan Han , Saugata Dutta , Ohmed Khilji , Duo Zhang , Xiaoyun Wang

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引用次数: 1

Abstract

Tissue inhibitors of metalloproteases (TIMPs) have caught the attention of many scientists due to their role in various physiological and pathological processes. TIMP-1, 2, 3, and 4 are known members of the TIMPs family. TIMPs exert their biological effects by, but are not limited to, inhibiting the activity of metalloproteases (MMPs). The balance between MMPs and TIMPs is critical for maintaining homeostasis of the extracellular matrix (ECM), while the imbalance between MMPs and TIMPs can lead to pathological changes, such as cancer. In this review, we summarized the current knowledge of TIMP-1 in several pulmonary diseases namely, acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pneumonia, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and pulmonary fibrosis. Considering the potential of TIMP-1 serving as a non-invasive diagnostic and/or prognostic biomarker, we also reviewed the circulating TIMP-1 levels in translational and clinical studies.

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TIMP-1及其在肺部疾病中的潜在诊断和预后价值

金属蛋白酶组织抑制剂（TIMPs）因其在各种生理和病理过程中的作用而引起了许多科学家的注意。TIMP-1、2、3和4是TIMPs家族的已知成员。TIMP通过但不限于抑制金属蛋白酶（MMPs）的活性来发挥其生物学作用。MMPs和TIMPs之间的平衡对于维持细胞外基质（ECM）的稳态至关重要，而MMPs和TIMPs之间的不平衡可能导致病理变化，如癌症。在这篇综述中，我们总结了TIMP-1在几种肺部疾病中的最新知识，即急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）、肺炎、哮喘、慢性阻塞性肺病（COPD）、囊性纤维化和肺纤维化。考虑到TIMP-1作为非侵入性诊断和/或预后生物标志物的潜力，我们还回顾了转化和临床研究中的循环TIMP-1水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese medical journal pulmonary and critical care medicine Critical Care and Intensive Care Medicine, Infectious Diseases, Pulmonary and Respiratory Medicine

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0.40

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