Detection of several respiratory viruses with Surface-Enhanced Raman Spectroscopy coupled with Artificial Intelligence

Delphine Garsuault , Sanaa El Messaoudi , Mookkan Prabakaran , Ian Cheong , Anthony Boulanger , Marion Schmitt-Boulanger
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Abstract

Diagnoses of viral infections are a challenge when facing a crisis like COVID-19, where their speed and reliability are critical to minimize diseases spread. The gold standard of diagnostics, quantitative Polymerase Chain Reaction, is time- and reagent-consuming and requires qualified personnel. Therefore, it is necessary to find new detection techniques to overcome these barriers. Surface Enhanced Raman Spectroscopy (SERS) is a detection method, based on light and metallic particles admixed with the samples, already used in different fields of research. In this study, we discriminate three respiratory viruses using a combination of SERS and Artificial Intelligence (AI). Our technique appears to be fast, reproducible, and reliable, achieving between 95 % and 100 % of accuracy, standing out as a powerful tool usable for viral diagnostics.

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结合人工智能的表面增强拉曼光谱检测几种呼吸道病毒
在面临新冠肺炎等危机时,病毒感染的诊断是一个挑战,其速度和可靠性对于最大限度地减少疾病传播至关重要。诊断学的黄金标准,定量聚合酶链式反应,需要时间和试剂,需要合格的人员。因此,有必要找到新的检测技术来克服这些障碍。表面增强拉曼光谱(SERS)是一种基于光和金属颗粒与样品混合的检测方法,已用于不同的研究领域。在这项研究中,我们使用SERS和人工智能(AI)的组合来区分三种呼吸道病毒。我们的技术看起来快速、可重复、可靠,准确率在95%到100%之间,是一种可用于病毒诊断的强大工具。
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