Functional Diversity in Radiolabeled Nanoceramics and Related Biomaterials for the Multimodal Imaging of Tumors

IF 3.8 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY ACS Bio & Med Chem Au Pub Date : 2023-08-08 DOI:10.1021/acsbiomedchemau.3c00021
David G. Calatayud*, Marina Lledos, Federico Casarsa and Sofia I. Pascu*, 
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Abstract

Nanotechnology advances have the potential to assist toward the earlier detection of diseases, giving increased accuracy for diagnosis and helping to personalize treatments, especially in the case of noncommunicative diseases (NCDs) such as cancer. The main advantage of nanoparticles, the scaffolds underpinning nanomedicine, is their potential to present multifunctionality: synthetic nanoplatforms for nanomedicines can be tailored to support a range of biomedical imaging modalities of relevance for clinical practice, such as, for example, optical imaging, computed tomography (CT), magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). A single nanoparticle has the potential to incorporate myriads of contrast agent units or imaging tracers, encapsulate, and/or be conjugated to different combinations of imaging tags, thus providing the means for multimodality diagnostic methods. These arrangements have been shown to provide significant improvements to the signal-to-noise ratios that may be obtained by molecular imaging techniques, for example, in PET diagnostic imaging with nanomaterials versus the cases when molecular species are involved as radiotracers. We surveyed some of the main discoveries in the simultaneous incorporation of nanoparticulate materials and imaging agents within highly kinetically stable radio-nanomaterials as potential tracers with (pre)clinical potential. Diversity in function and new developments toward synthesis, radiolabeling, and microscopy investigations are explored, and preclinical applications in molecular imaging are highlighted. The emphasis is on the biocompatible materials at the forefront of the main preclinical developments, e.g., nanoceramics and liposome-based constructs, which have driven the evolution of diagnostic radio-nanomedicines over the past decade.

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放射标记纳米陶瓷和相关生物材料在肿瘤多模态成像中的功能多样性
纳米技术的进步有可能有助于早期发现疾病,提高诊断的准确性,并有助于个性化治疗,尤其是在癌症等非传染性疾病的情况下。纳米颗粒是支撑纳米药物的支架,其主要优势是其具有多功能性的潜力:纳米药物的合成纳米平台可以定制为支持一系列与临床实践相关的生物医学成像模式,例如光学成像、计算机断层扫描(CT)、磁共振成像(MRI),单光子发射计算机断层扫描(SPECT)和正电子发射断层扫描(PET)。单个纳米颗粒有可能结合大量造影剂单元或成像示踪剂,封装和/或结合到成像标签的不同组合,从而为多模态诊断方法提供手段。与分子物种作为放射性示踪剂参与的情况相比,这些布置已被证明对可以通过分子成像技术获得的信噪比提供了显著的改进,例如,在使用纳米材料的PET诊断成像中。我们调查了在高度动力学稳定的放射性纳米材料中同时掺入纳米颗粒材料和成像剂作为具有(预)临床潜力的潜在示踪剂的一些主要发现。探索了功能的多样性和合成、放射性标记和显微镜研究的新进展,并强调了分子成像的临床前应用。重点是处于主要临床前发展前沿的生物相容性材料,例如纳米陶瓷和基于脂质体的构建体,它们在过去十年中推动了诊断性放射性纳米药物的发展。
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来源期刊
ACS Bio & Med Chem Au
ACS Bio & Med Chem Au 药物、生物、化学-
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: ACS Bio & Med Chem Au is a broad scope open access journal which publishes short letters comprehensive articles reviews and perspectives in all aspects of biological and medicinal chemistry. Studies providing fundamental insights or describing novel syntheses as well as clinical or other applications-based work are welcomed.This broad scope includes experimental and theoretical studies on the chemical physical mechanistic and/or structural basis of biological or cell function in all domains of life. It encompasses the fields of chemical biology synthetic biology disease biology cell biology agriculture and food natural products research nucleic acid biology neuroscience structural biology and biophysics.The journal publishes studies that pertain to a broad range of medicinal chemistry including compound design and optimization biological evaluation molecular mechanistic understanding of drug delivery and drug delivery systems imaging agents and pharmacology and translational science of both small and large bioactive molecules. Novel computational cheminformatics and structural studies for the identification (or structure-activity relationship analysis) of bioactive molecules ligands and their targets are also welcome. The journal will consider computational studies applying established computational methods but only in combination with novel and original experimental data (e.g. in cases where new compounds have been designed and tested).Also included in the scope of the journal are articles relating to infectious diseases research on pathogens host-pathogen interactions therapeutics diagnostics vaccines drug-delivery systems and other biomedical technology development pertaining to infectious diseases.
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