Parametrization of Catalytic Organic Reactions with Convex Hammett Plots

Abstract

Quantification is essential to fairly compare between synthetic reactions in chemistry. Here we propose two new parameters called “adapted sensitivity constant” (ρ_adap) and “substrate electronics adaptability” (SEA), easily obtainable from Hammett plots, to assess the ability of a (catalytic) reaction to transform substrates with opposing electronics. These new parameters allow one to list reactions, catalyzed or not, as a function of substrate scope.