Regional serotonin terminal density in aging human brain: A [11C]DASB PET study

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2023-01-01 DOI:10.1016/j.nbas.2023.100071
Prabesh Kanel , Robert A. Koeppe , Vikas Kotagal , Stiven Roytman , Martijn L.T.M. Muller , Nicolaas I. Bohnen , Roger L. Albin
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引用次数: 1

Abstract

There are conflicting results regarding regional age-related changes in serotonin terminal density in human brain. Some imaging studies suggest age-related declines in serotoninergic terminals and perikarya. Other human imaging studies and post-mortem biochemical studies suggest stable brain regional serotoninergic terminal densities across the adult lifespan. In this cross-sectional study, we used [11C]3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile positron emission tomography to quantify brain regional serotonin transporter density in 46 normal subjects, ranging from 25 to 84 years of age. Both voxel-based analyses, using sex as a covariate, and volume-of-interest-based analyses were performed. Both analyses revealed age-related declines in [11C]3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile binding in numerous brain regions, including several neocortical regions, striatum, amygdala, thalamus, dorsal raphe, and other subcortical regions. Similar to some other neurotransmitter systems of subcortical origin, we found evidence of age-related declines in regional serotonin terminal density in both cortical and subcortical regions.

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衰老人脑区域5 -羟色胺末端密度:A [11C]DASB PET研究
关于人类大脑中血清素终末密度与年龄相关的区域变化,存在着相互矛盾的结果。一些影像学研究表明,与年龄相关的血清素能终末和perikarya下降。其他人体成像研究和死后生化研究表明,在整个成年期内,大脑区域血清素能末端密度稳定。在这项横断面研究中,我们使用[11C]3-氨基-4-(2-二甲基氨基甲基苯基硫烷基)-苄腈正电子发射断层扫描来量化46名年龄在25至84岁之间的正常受试者的大脑区域5-羟色胺转运蛋白密度。使用性别作为协变量的基于体素的分析和基于感兴趣体积的分析都进行了。这两项分析都显示,[11C]3-氨基-4-(2-二甲基氨基甲基苯基硫烷基)-苄腈在许多大脑区域的结合与年龄相关,包括几个新皮质区域、纹状体、杏仁核、丘脑、中缝背侧和其他皮质下区域。与皮层下起源的其他一些神经递质系统类似,我们发现了皮层和皮层下区域5-羟色胺终末密度与年龄相关下降的证据。
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Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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