Una imagen PET amiloide estática del primer minuto (FMF) se correlaciona con [18F]FDG PET en pacientes con afasia progresiva primaria

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Revista Espanola De Medicina Nuclear E Imagen Molecular Pub Date : 2023-07-01 DOI:10.1016/j.remn.2022.10.001

A. Gómez-Grande , A.P. Seiffert , A. Villarejo-Galende , M. González-Sánchez , S. Llamas-Velasco , H. Bueno , E.J. Gómez , M.J. Tabuenca , P. Sánchez-González

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Abstract

Objective

To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with ¹⁸F-labeled amyloid-binding radiotracers and brain [¹⁸F]FDG PET in patients with primary progressive aphasia (PPA).

Material and methods

The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [¹⁸F]FDG PET images and Pearson's correlation coefficients are calculated.

Results

SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r = .94 ± .06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.

Conclusions

The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.

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原发性进行性失语症患者第一分钟静态淀粉样蛋白PET图像与[18F]FDG PET相关

目的研究原发性进行性失语症（PPA）患者用18F标记的淀粉样蛋白结合放射性示踪剂获得的第一分钟帧（FMF）静态PET图像与脑[18F]FDG PET之间的相关性。材料和方法研究队列包括17名被诊断为PPA的患者，其分布如下：9名非流动变体PPA，4名同源变体PPA，1名语义变体PPA，3名不可分类PPA。从FMF中提取区域SUVR，并计算其相应的[18F]FDG PET图像和Pearson相关系数。结果两张图像的SUVR显示出相似的局部脑改变模式。患者内相关性分析得出的平均系数为r=.94±.06。研究队列的区域患者间相关系数大于0.81。放射性示踪剂特异性和变体特异性亚短序列在图像之间的相似性上没有差异。结论静态FMF可能是文献中提出的动态早期淀粉样蛋白PET的有效替代品，也是淀粉样蛋白研究中诊断和分类PPA的神经退行性生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Espanola De Medicina Nuclear E Imagen Molecular RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.10

自引率

16.70%

发文量

审稿时长

24 days

期刊介绍： The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles.