Three new sesquiterpenes from roots of Curcuma longa

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL Chinese Herbal Medicines Pub Date : 2023-07-01 DOI:10.1016/j.chmed.2022.11.007

Jie Zhang , Xiaorui Ma , Wei Wang , Caixia Wu , Ben Ma , Chong Yu , Haifeng Wang

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Abstract

Objective

To study the chemical constituents from the roots of Curcuma longa.

Methods

The structures of the compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis.

Results

Two new sesquiterpene compounds (1S,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (1), (1R,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one (2), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one (3) together with three known compounds ar-turmerone (4), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (5) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (6) were isolated from C. longa root extract with 95% ethanol.

Conclusion

In the study, three new compounds were isolated from C. longa, and their absolute configurations were determined.

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姜黄根中的三种新倍半萜

目的研究姜黄根的化学成分。方法通过广泛的波谱分析，包括1D和2D NMR、MS、UV和CD分析，对化合物的结构进行了鉴定。结果两个新的倍半萜化合物（1S，2R，5R，7S，8R）-2,8-环氧-5-羟基isabola-3,10-二烯-9-酮（1），（1R，2R、5R、7S，8 R）-2:8-环氧-5-羟isabola-3/10-二烯-9-烯（2），以及一个新的天然产物6-（4-羟基甲基苯基）-2-甲基庚-2-烯-4-酮（3）和三个已知化合物ar turmerone（4），用95%乙醇从龙胆根提取物中分离出2-甲基-6-（4-羟基苯基-3-甲基）-2-庚烯-4-酮（5）和2-甲基-6-。结论本研究从龙舌兰中分离得到三个新化合物，并确定了它们的绝对构型。

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