SARS-CoV-2 and thyroid diseases

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2023-10-17 DOI:10.1016/j.jtauto.2023.100214
Małgorzata Staruszkiewicz , Anna Pituch-Noworolska , Szymon Skoczen
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Abstract

SARS-CoV-2 virus responsible for acute respiratory disease affected other organs leading to co-existence symptoms or complications. Thyroid gland was one of them due to expression of angiotensin-converting enzyme 2 (ACE2), the protein facilitating viral binding to the host cells. Moreover, thyroid gland, important for regulation of hormonal network, is extremely sensitive to any changes in homeostasis and metabolism. It was shown, that COVID-19 was associated with induction of thyroid disease or increasing existing functional disturbances or autoimmune process. Thyroid diseases are mainly based on immunological pathomechanism although the relation between immune system and thyroid function is bidirectional e.g. thyroid hormones modulate specific immune responses, including cell-mediated immunity, NK cell activity, the production of antiviral interferon (IFN) and proliferation of T- and B-lymphocytes. The effects of COVID-19 and mRNA vaccine on thyroid function and diseases are discussed.

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SARS-CoV-2和甲状腺疾病
导致急性呼吸道疾病的SARS-CoV-2病毒影响其他器官,导致症状或并发症并存。甲状腺是其中之一,因为它表达血管紧张素转换酶2 (ACE2),一种促进病毒与宿主细胞结合的蛋白质。此外,甲状腺是调节激素网络的重要器官,对体内平衡和代谢的任何变化都极为敏感。研究表明,COVID-19与甲状腺疾病的诱导或现有功能障碍或自身免疫过程的增加有关。尽管免疫系统与甲状腺功能之间的关系是双向的,但甲状腺疾病的发病机制主要基于免疫机制,如甲状腺激素调节特异性免疫反应,包括细胞介导的免疫、NK细胞活性、抗病毒干扰素(IFN)的产生以及T淋巴细胞和b淋巴细胞的增殖。讨论新冠病毒和mRNA疫苗对甲状腺功能和疾病的影响。
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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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