Hydroxychloroquine Therapy and Serum Immunoglobulin Levels in Women with IgG Subclass Deficiency and Systemic Lupus Erythematosus, Sjögren Syndrome, and Rheumatoid Arthritis: A Retrospective Study

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-04-11 DOI:10.1007/s00005-022-00652-x
James C. Barton, J. Clayborn Barton, Luigi F. Bertoli
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Abstract

Hydroxychloroquine (HCQ) therapy decreased immunoglobulin (Ig) levels in patients with Sjögren syndrome (SS) and rheumatoid arthritis (RA) in previous studies. We found no report of Ig levels of women with IgG subclass deficiency (IgGSD) and systemic lupus erythematosus (SLE), SS, or RA treated with HCQ. We retrospectively evaluated IgG, IgG subclass, IgA, and IgM levels and other characteristics of women at IgGSD diagnosis who did and did not take HCQ for SLE, SS, or RA. There were 132 women (48 subnormal IgG1 only, 49 combined subnormal IgG1/IgG3, and 35 subnormal IgG3 only). Mean age was 49 ± 13 years. Twenty-two women with SLE, SS, RA, or combination thereof reported HCQ ≥ 200 mg/day ≥ 6 months. In each IgGSD subtype, median Ig levels of women who took HCQ were not significantly lower than those of women who did not take HCQ. Women with combined subnormal IgG1/IgG3 who took HCQ had greater median IgG2 than women who did not take HCQ (4.89 g/L (range 4.43, 4.94) vs. 2.57 g/L (1.21, 6.44), respectively; p = 0.0123). Regressions on IgG1, IgG2, and IgG3 revealed positive associations with HCQ therapy (p = 0.0043, 0.0037, and 0.0139, respectively). There were no significant Ig associations with age, SLE, SS, or RA as independent variables. HCQ therapy of SLE, SS, or RA in women with IgGSD was not associated with significantly lower IgG, IgG subclass, IgA, or IgM levels. IgG1, IgG2, and IgG3 were positively associated with HCQ therapy, after adjustment for other variables.

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羟氯喹治疗和血清免疫球蛋白水平在妇女IgG亚类缺乏和系统性红斑狼疮,Sjögren综合征,类风湿关节炎:回顾性研究
在先前的研究中,羟氯喹(HCQ)治疗可降低Sjögren综合征(SS)和类风湿性关节炎(RA)患者的免疫球蛋白(Ig)水平。我们没有发现IgG亚类缺乏症(IgGSD)和系统性红斑狼疮(SLE)、SS或RA接受HCQ治疗的女性IgG水平的报告。我们回顾性地评估了IgG、IgG亚类、IgA和IgM水平以及诊断为IgGSD的女性在SLE、SS或RA中使用和未使用HCQ的其他特征。132名女性(48名仅IgG1亚正常,49名IgG1/IgG3合并亚正常,35名仅IgG3亚正常)。平均年龄49±13岁。22名SLE、SS、RA或合并患者报告HCQ≥200mg /天≥6个月。在每一种IgGSD亚型中,服用HCQ的女性的平均Ig水平并不显著低于未服用HCQ的女性。合并IgG1/IgG3不正常的妇女服用HCQ的IgG2中位数高于未服用HCQ的妇女(分别为4.89 g/L(范围4.43,4.94)和2.57 g/L(范围1.21,6.44);p = 0.0123)。IgG1、IgG2和IgG3的回归显示与HCQ治疗呈正相关(p分别= 0.0043、0.0037和0.0139)。Ig与年龄、SLE、SS或RA作为自变量无显著关联。患有IgGSD的女性SLE、SS或RA的HCQ治疗与IgG、IgG亚类、IgA或IgM水平的显著降低无关。在校正其他变量后,IgG1、IgG2和IgG3与HCQ治疗呈正相关。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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