Pushing Differential Sensing Further: The Next Steps in Design and Analysis of Bio-Inspired Cross-Reactive Arrays

IF 3.4 Q2 CHEMISTRY, ANALYTICAL Analysis & sensing Pub Date : 2023-01-10 DOI:10.1002/anse.202200095
Dr. Hazel A. Fargher, Dr. Simon d'Oelsnitz, Daniel J. Diaz, Prof. Eric V. Anslyn
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Abstract

Differential sensing is a technique that uses an array of cross-reactive receptors to create a unique fingerprint to detect analytes. Over the past two decades significant progress in the field has highlighted the power of this approach, enabling detection with commercially available or synthetically simple sensors, discrimination of structurally similar and challenging analytes, and low concentration detection. In this Concept paper, we briefly review developments in the field and highlight areas for future exploration. We believe there is still much room to grow, particularly in designing biosensor arrays, achieving simultaneous quantification of multiple analytes (i. e., multiplexing), and implementation of more advanced machine learning algorithms in array response analysis.

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进一步推动差分传感:生物激励交叉反应阵列设计和分析的下一步
差异传感是一种使用交叉反应受体阵列创建独特指纹以检测分析物的技术。在过去的二十年里,该领域的重大进展突出了这种方法的威力,能够用商业上可用的或合成简单的传感器进行检测,识别结构相似且具有挑战性的分析物,以及低浓度检测。在这篇概念文件中,我们简要回顾了该领域的发展,并强调了未来勘探的领域。我们相信仍有很大的发展空间,特别是在设计生物传感器阵列、实现多种分析物的同时定量方面。 e.多路复用),以及在阵列响应分析中实现更先进的机器学习算法。
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