Retrospective matched cohort study of incidence rates and excess length of hospital stay owing to pressure injuries in an Asian setting

Nicholas Graves, Raju Maiti, Fazila Abu Bakar Aloweni, Ng Yi Zhen, Ang Shin Yuh, Priya Bishnoi, Tze Tec Chong, David Carmody, Keith Harding
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Abstract

Background

Little is known about stage 1 and 2 pressure injuries that are health care-acquired. We report incidence rates of health care-acquired stage 1 and stage 2 pressure injuries, and, estimate the excess length of stay using four competing analytic methods. We discuss the merits of the different approaches.

Methods

We calculated monthly incidence rates for stage 1 and 2 health care-acquired pressure injuries occurring in a large Singapore acute care hospital. To estimate excess stay, we conducted unadjusted comparisons with a control cohort, performed linear regression and then generalized linear regression with a gamma distribution. Finally, we fitted a simple state-based model. The design for the cost attribution work was a retrospective matched cohort study.

Results

Incidence rates in 2016 were 0.553% (95% confidence interval [CI] 0.55, 0.557) and 0.469% (95% CI 0.466, 0.472) in 2017. For data censored at 60 days’ maximum stay, the unadjusted comparisons showed the highest excess stay at 17.68 (16.43-18.93) days and multi-state models showed the lowest at 1.22 (0.19, 2.23) days.

Conclusions

Poor-quality methods for attribution of excess length of stay to pressure injury generate inflated estimates that could mislead decision makers. The findings from the multi-state model, which is an appropriate method, are plausible and illustrate the likely bed-days saved from lowering the risk of these events. Stage 1 and 2 pressure injuries are common and increase costs by prolonging the length of stay. There will be economic value investing in prevention. Using biased estimates of excess length of stay will overstate the potential value of prevention.

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亚洲地区因压力损伤导致的发病率和住院时间过长的回顾性配对队列研究
背景对医疗保健获得的第1和第2阶段压力损伤知之甚少。我们报告了医疗保健获得性1期和2期压力损伤的发生率,并使用四种相互竞争的分析方法估计了超额住院时间。我们讨论了不同方法的优点。方法我们计算了新加坡一家大型急性护理医院发生的1期和2期卫生保健获得性压力损伤的月发病率。为了估计超额停留时间,我们与对照队列进行了未经调整的比较,进行了线性回归,然后进行了伽马分布的广义线性回归。最后,我们拟合了一个简单的基于状态的模型。成本归因工作的设计是一项回顾性配对队列研究。结果2016年的发病率为0.553%(95%可信区间[CI]0.55,0.557),2017年为0.469%(95%置信区间0.466,0.472)。对于在最长停留60天时审查的数据,未经调整的比较显示,超额停留最高为17.68天(16.43-18.93),多状态模型显示最低为1.22天(0.192.23)。结论将住院时间过长归因于压力损伤的方法质量较差,导致估计值过高,可能会误导决策者。多状态模型是一种合适的方法,其发现是合理的,并说明了降低这些事件风险可能节省的卧床天数。第1阶段和第2阶段的压力损伤是常见的,并且通过延长住院时间来增加成本。投资于预防将具有经济价值。对超额停留时间使用有偏见的估计会夸大预防的潜在价值。
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