Advances in the treatment of solid tumors in children and adolescents

Cancer Innovation Pub Date : 2023-04-08 DOI:10.1002/cai2.66
Jing Tian, Jiayu Wang, Sidan Li
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Abstract

Tumor is one of the leading causes of death in children (0 to 14-year-old) and adolescents (15 to 19-year-old) worldwide. Unlike adult tumors, childhood and adolescent tumors are unique in their type, molecular characteristics, and pathogenesis, and their treatment involves many challenges. In recent years, with the development of a large number of clinical studies, the survival rate of children and adolescents with tumors has improved significantly. The extensive research and application of optimized treatment regimens and new targeted drugs have led to new hope for the treatment of childhood and adolescent tumors. This article reviews the clinical and basic research and treatment of childhood and adolescent tumors and provides new ideas for the future development of precise treatment of childhood and adolescent tumors.

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儿童青少年实体瘤治疗进展
肿瘤是全球儿童(0至14岁)和青少年(15至19岁)死亡的主要原因之一。与成人肿瘤不同,儿童和青少年肿瘤在类型、分子特征和发病机制方面是独特的,其治疗涉及许多挑战。近年来,随着大量临床研究的开展,儿童青少年肿瘤患者的生存率明显提高。优化治疗方案和新靶向药物的广泛研究和应用为儿童和青少年肿瘤的治疗带来了新的希望。本文综述了儿童青少年肿瘤的临床和基础研究与治疗,为儿童青少年肿瘤精准治疗的未来发展提供了新的思路。
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