Solution and solid-state 33S NMR studies of 33S-labeled taurine

IF 1.9 3区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Magnetic Resonance in Chemistry Pub Date : 2023-08-23 DOI:10.1002/mrc.5387
Yuichi Masuda, Shinobu Ohki, Yuuki Mogami, Kenzo Deguchi, Kenjiro Hashi, Atsushi Goto, Tadashi Shimizu, Kazuhiko Yamada
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Abstract

Sulfur-33(33S) stable-isotope labeled taurine, 2-aminoethanesulfonic acid, has been synthesized, and a series of solution and solid-state 33S nuclear magnetic resonance (NMR) experiments at 14.1 and 18.8 T, respectively, have been carried out at room temperature. The single peak of a solution 33S NMR spectrum in 0.1-mM [33S]-taurine in D2O can be observed with the signal-to-noise (S/N) ratio of 9 in 40,000 scans, which paves the way toward in vivo analysis of pharmacokinetics and metabolism of 33S-labeled taurine. Undistorted magic-angle-spinning (MAS) and static 33S NMR spectra of polycrystalline [33S]-taurine are observed with sufficient S/N ratios for analysis, and the magnitudes of 33S EFG and CS tensors can be obtained.

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33S标记牛磺酸的溶液和固态33S NMR研究
合成了硫33(33S)稳定同位素标记的牛磺酸2-氨基乙磺酸,并在室温下分别在14.1和18.8T下进行了一系列溶液和固体33S核磁共振(NMR)实验。D2O中0.1-mM[33S]-牛磺酸溶液的33S NMR谱的单峰可以在40000次扫描中观察到,信噪比(S/N)为9,这为体内分析33S标记的牛磺酸的药代动力学和代谢铺平了道路。观察了多晶[33S]-牛磺酸的无畸变魔角自旋(MAS)和静态33S NMR谱,具有足够的S/N比进行分析,可以获得33S EFG和CS张量的大小。
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来源期刊
CiteScore
4.70
自引率
10.00%
发文量
99
审稿时长
1 months
期刊介绍: MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published. The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.
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