Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform (3/2023)

BMEMat Pub Date : 2023-09-28 DOI:10.1002/bmm2.12050

Ping Li, Chao Wang, Jiaoyan Qiu, Fangteng Song, Yuzhen Huang, Yunhong Zhang, Kai Zhang, Hao Ji, Yuanhua Sang, Jonny J. Blaker, Yu Zhang, Lin Han

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Abstract

In this article number 10.1002/bmm2.12040, Ping Li, Chao Wang and their co-workers systematically studied the inhibitory effects of zinc oxide nanorods (ZnO NRs) on breast cancer cells. They found that the ZnO NRs inhibited the migration and growth of cell populations, as well as suppressed the secretion of multiple cytokines through a microfluidic platform. Subsequently, they utilized a single-cell chip to explore the cell heterogeneity before and after the inhibition. Based on the different behaviors exhibited by the cells, they reclassified cell clusters and ultimately discovered that ZnO NRs had a weaker inhibitory effect on highly invasive and metastatic cell populations. This offers a reasonable risk analysis for the potential application of ZnO NRs in cancer therapy.

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氧化锌纳米棒阵列通过单细胞微流体平台实时筛选细胞因子对乳腺癌症细胞的抑制作用（3/2023）

在这篇编号为10.1002/bmm2.12040的文章中，李平、王超及其同事系统地研究了氧化锌纳米棒（ZnO-NRs）对乳腺癌症细胞的抑制作用。他们发现ZnO NRs通过微流体平台抑制细胞群的迁移和生长，并抑制多种细胞因子的分泌。随后，他们利用单细胞芯片来探索抑制前后的细胞异质性。基于细胞表现出的不同行为，他们对细胞簇进行了重新分类，并最终发现ZnO NRs对高侵袭性和转移性细胞群体的抑制作用较弱。这为ZnO NRs在癌症治疗中的潜在应用提供了合理的风险分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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