Cover Feature: Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications? (Anal. Sens. 5/2023)

Abstract

The cover feature image shows a cartoon representation of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), which can produce in-source fragmentation of lipids and cause artificial annotations from biological samples, particularly for phosphatidic acids. Whether these annotations are endogenous or artificial may be assessed by comparison with nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI-MSI). More information can be found in the Research Article by Christopher Anderton and co-workers.