Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice

IF 3.3 4区医学 Q3 IMMUNOLOGY Immunology letters Pub Date : 2023-11-01 DOI:10.1016/j.imlet.2023.10.005

Hong Liu , Yuxiang Wang , Qingqing Zhang , Chuanchuan Liu , Yougang Ma , Pan Huang , Rili Ge , Lan Ma

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Abstract

The role of inflammation in pulmonary hypertension is gradually gaining increasing research attention. However, no previous study has evaluated the characteristics of inflammation during chronic hypoxia-induced pulmonary hypertension. Therefore, the aim of this study was to investigate the characteristics of the inflammatory process involved in hypoxia-induced pulmonary hypertension in mice. The current study evaluated from day 4 to day 28 of hypoxia, the PAAT and PAAT/PET decreased, accompanied by pulmonary vascular remodeling and right ventricular hypertrophy, as well as increased numbers of CD68 macrophages. The expression of the pro-inflammatory factors IL-1β and IL-33 increased, but decreased on day 28. The expression of IL-12 increased from day 4 to day 28, whereas that of the anti-inflammatory factor IL-10 in lung tissue decreased. Furthermore, the expression of the IL-33/ST2 signaling pathway also increased over time under hypoxic conditions. In conclusion, pulmonary artery remodeling in HPH mice worsens progressively in a time-dependent manner, with inflammatory cell infiltration predominating in the early stage and pulmonary vascular remodeling occurring in the later stage.

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巨噬细胞来源的炎症促进缺氧诱导的肺动脉高压小鼠肺血管重塑

炎症在肺动脉高压中的作用逐渐受到越来越多的研究关注。然而，尚无研究评估慢性低氧肺动脉高压期间炎症的特征。因此，本研究的目的是探讨小鼠缺氧引起的肺动脉高压炎症过程的特点。本研究评估缺氧第4天至第28天，PAAT和PAAT/PET降低，伴肺血管重构和右心室肥厚，CD68巨噬细胞数量增加。促炎因子IL-1β和IL-33的表达在第28天升高，但降低。第4 ~ 28天肺组织IL-12表达升高，抗炎因子IL-10表达降低。此外，在缺氧条件下，IL-33/ST2信号通路的表达也随着时间的推移而增加。综上所述，HPH小鼠的肺动脉重构以时间依赖性的方式逐渐恶化，早期以炎症细胞浸润为主，后期发生肺血管重构。

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.