Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES Genes Brain and Behavior Pub Date : 2023-10-24 DOI:10.1111/gbb.12872
Hannah L. Peter, Marina Giglberger, Fabian Streit, Josef Frank, Ludwig Kreuzpointner, Marcella Rietschel, Brigitte M. Kudielka, Stefan Wüst
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Abstract

Genetic factors contribute significantly to interindividual differences in the susceptibility to stress-related disorders. As stress can also be conceptualized as environmental exposure, controlled gene–environment interaction (GxE) studies with an in-depth phenotyping may help to unravel mechanisms underlying the interplay between genetic factors and stress. In a prospective-longitudinal quasi-experimental study, we investigated whether polygenic scores (PGS) for depression (DEP-PGS) and neuroticism (NEU-PGS), respectively, were associated with responses to chronic stress in daily life. We examined law students (n = 432) over 13 months. Participants in the stress group experienced a long-lasting stress phase, namely the preparation for the first state examination for law students. The control group consisted of law students without particular stress exposure. In the present manuscript, we analyzed perceived stress levels assessed at high frequency and in an ecologically valid manner by ambulatory assessments as well as depression symptoms and two parameters of the cortisol awakening response. The latter was only assessed in a subsample (n = 196). No associations between the DEP-PGS and stress-related variables were found. However, for the NEU-PGS we found a significant GxE effect. Only in individuals experiencing academic stress a higher PGS for neuroticism predicted stronger increases of perceived stress levels until the exam. At baseline, a higher NEU-PGS was associated with higher perceived stress levels in both groups. Despite the small sample size, we provide preliminary evidence that the genetic disposition for neuroticism is associated with stress level increases in daily life during a long-lasting stress period.

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抑郁和神经质多基因评分与长期压力期日常生活感知压力的关系
遗传因素对应激相关疾病易感性的个体间差异有显著影响。由于压力也可以被概念化为环境暴露,具有深入表型的受控基因-环境相互作用(GxE)研究可能有助于揭示遗传因素和压力之间相互作用的机制。在一项前瞻性纵向准实验研究中,我们分别调查了抑郁症(DEP-PGS)和神经质(NEU-PGS)的多基因评分(PGS)是否与日常生活中对慢性压力的反应有关。我们调查了法学院的学生(n = 432)超过13 月。压力组的参与者经历了一个长期的压力阶段,即为法律系学生的第一次国家考试做准备。对照组由没有特别压力暴露的法律系学生组成。在本手稿中,我们分析了通过动态评估以生态有效的方式高频评估的感知压力水平,以及抑郁症状和皮质醇觉醒反应的两个参数。后者仅在子样本(n = 196)。DEP-PGS和压力相关变量之间没有发现关联。然而,对于NEU-PGS,我们发现了显著的GxE效应。只有在经历学业压力的个体中,神经质的PGS越高,在考试之前感知压力水平的增加就越大。在基线时,两组中NEU-PGS越大,感知压力水平越高。尽管样本量很小,但我们提供了初步证据,证明神经质的遗传倾向与长期压力期日常生活中压力水平的增加有关。
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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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