Measurement of GFAP in Nasal Exudate in the Differential Diagnosis between Ischemic Stroke and Intracerebral Hemorrhage.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY Cerebrovascular Diseases Pub Date : 2024-01-01 Epub Date: 2023-10-25 DOI:10.1159/000534693

Carmen García-Cabo, Pablo Rioboó-Legaspi, Lorena Benavente-Fernández, Estefanía Costa-Rama, María Teresa Fernández-Abedul, Sergio Calleja-Puerta

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Abstract

Background: Differential diagnosis between ischemic stroke (IS) and intracerebral hemorrhage (ICH) is a great challenge. Recently, the discovery of cerebral lymphatic drainage toward the nostrils suggested nasal exudate (NE) as a new source for measuring biomarkers from neural damage.

Objectives: In this study, we sought to confirm whether glial fibrillary acidic protein (GFAP) levels in NE could identify ICH.

Methods: GFAP in nasal exudate (nGFAP) was studied in 5 IS and 5 ICH patients. All patients underwent neurological examination, brain computed tomography, laboratory tests, and measurement of nGFAP and serum GFAP.

Results: We found higher concentrations in ICH patients (p = 0.02). The area under the ROC curve for IS/ICH discrimination was 0.840, with a cut-off point of 0.06 pg/mg for 100% sensitivity and 80% specificity.

Conclusions: These findings suggest that nGFAP could be a useful biomarker for differential diagnosis between IS and ICH and opens a potential field of study for other biomarkers in NE in neurological disorders.

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鼻分泌物中GFAP的测定对缺血性和出血性脑卒中的鉴别诊断。

引言：缺血性脑卒中（IS）和脑出血（ICH）的鉴别诊断是一个巨大的挑战。最近，大脑淋巴管引流至鼻孔的发现表明，鼻腔分泌物（NE）是测量神经损伤生物标志物的新来源。我们试图确认NE中的胶质纤维酸性蛋白（GFAP）水平是否可以识别ICH。方法：对5例IS和5例ICH患者鼻分泌物中的GFAP进行研究。所有患者均接受了神经系统检查、脑计算机断层扫描、实验室测试以及nGFAP和血清GFAP的测量。结果：ICH患者血药浓度较高（p=0.02），结论：这些发现表明nGFAP可能是区分IS和ICH的有用生物标志物，并为神经系统疾病NE的其他生物标志物开辟了潜在的研究领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.