Prevalence of Extended-Spectrum Beta-Lactamase Resistance and CTX-M-Group 1 Gene in Escherichia coli from the Water and Sediment of Urbanized Mangrove Ecosystems of Kerala.

IF 2.3 4区医学 Q3 INFECTIOUS DISEASES Microbial drug resistance Pub Date : 2023-12-01 Epub Date: 2023-10-26 DOI:10.1089/mdr.2023.0089

Gopika Sivan, Divya P Sukumaran, Akhil Prakash Ezhuthanikkunnel, Mohamed Hatha Ammanamveetil Abdulla

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Abstract

The study aimed to determine the prevalence of extended-spectrum β-lactamase resistance and CTX-M-group 1 gene in Escherichia coli from the water and sediment of three urbanized mangrove ecosystems of Kerala. A total of 119 E. coli isolates were screened for antibiotic susceptibility to 16 antibiotics. According to the phylogenetic analysis of E. coli isolates, nonpathogenic group A and pathogenic group D (29.4% and 23.5%) were the predominant phylotypes found in water samples. The most frequent phylotypes found in sediment samples were nonpathogenic groups A and B1 (27.9% and 26.4%). The highest incidence of antibiotic resistance in E. coli was against cefotaxime and colistin (100%). A significant difference in the prevalence of CTX-M-group 1 gene was observed among E. coli isolates in water samples (p < 0.05). The results indicate a high prevalence of β-lactamase harboring E. coli in the mangrove ecosystems that can hamper mangrove-dependent aquaculture practices and human health.

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喀拉拉邦城市化红树林生态系统水和沉积物中大肠杆菌对β-内酰胺酶抗性和CTX-M 1组基因的扩展谱患病率。

本研究旨在确定喀拉拉邦三个城市化红树林生态系统的水和沉积物中大肠杆菌中超广谱β-内酰胺酶耐药性和CTX-M组1基因的患病率。共筛选了119株大肠杆菌对16种抗生素的耐药性。根据对大肠杆菌分离株的系统发育分析，在水样中发现的主要门型为非致病群A和致病群D（29.4%和23.5%）。在沉积物样品中发现的最常见的门型是非致病组A和B1（27.9%和26.4%）。大肠杆菌中抗生素耐药性的最高发生率是对头孢噻肟和粘菌素（100%）。在水样中的大肠杆菌分离株中观察到CTX-M组1基因的流行率存在显著差异（p 红树林生态系统中的大肠杆菌可能会阻碍依赖红树林的水产养殖做法和人类健康。

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来源期刊

Microbial drug resistance 医学-传染病学

CiteScore

6.00

自引率

3.80%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi-drug resistant clones of major pathogens that are widely documented in hospitals and the scientific community. The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a multidisciplinary forum for peer-reviewed original publications as well as topical reviews and special reports. MDR coverage includes: Molecular biology of resistance mechanisms Virulence genes and disease Molecular epidemiology Drug design Infection control.