Diego Alves Ferreira, Lorena Barbosa Cunha Macedo, Maria Paula Foss
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引用次数: 0
Abstract
Objective: Identifying neuropsychiatric symptoms (NPS) can aid in the early detection of Alzheimer's disease (AD); however, there is still a need for a greater consensus. This review aims to delineate the predominant NPS, compile a comprehensive list of the most commonly employed NPS assessment tools, and corroborate the principal findings regarding the link between NPS and neuropsychological assessment and neurobiological substrates. Methods: To conduct this scoping review, we followed the Preferred Reporting Items for Systematic Reviews guidelines and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). We searched for relevant articles published between 2017 and 2023 in MEDLINE, PsycINFO, PubMed, Web of Science, and Cochrane Library. Results: Of the 61 eligible articles, depression, anxiety, and apathy were the main NPSs. The Neuropsychiatric Inventory Questionnaire and Neuropsychiatric Inventory were the primary assessment tools used to evaluate NPS. Correlations between NPS severity and neurobiological markers were considered clinically significant. Furthermore, clinical procedures prioritized the use of global cognitive screening tools, assessments of executive functions, and functionality evaluations. Conclusion: Standardization of procedures is necessary because of the diversity of methods. The data show that NPS can predict the etiology, severity, form, and type of disease progression, serving as a precursor sign of AD. The results of the most common cognitive screening tools and NPS instruments provided an interesting overview of future clinical approaches.
目的:识别神经精神症状(NPS)有助于早期发现阿尔茨海默病(AD);然而,仍然需要达成更大的共识。本综述旨在描述主要的NPS,编制一份最常用的NPS评估工具的综合清单,并证实关于NPS与神经心理评估和神经生物学基础之间联系的主要发现。方法:为了进行范围界定审查,我们遵循了系统评价的首选报告项目指南和范围界定审查的荟萃分析扩展(PRISMA ScR)。我们在MEDLINE、PsycINFO、PubMed、Web of Science和Cochrane Library上搜索了2017年至2023年间发表的相关文章。结果:在61篇符合条件的文章中,抑郁、焦虑和冷漠是主要的NPS。神经精神问卷和神经精神问卷是用于评估NPS的主要评估工具。NPS严重程度和神经生物学标志物之间的相关性被认为具有临床意义。此外,临床程序优先使用全球认知筛查工具、执行功能评估和功能评估。结论:由于方法的多样性,程序的标准化是必要的。数据显示,NPS可以预测疾病进展的病因、严重程度、形式和类型,作为AD的前兆。最常见的认知筛查工具和NPS仪器的结果为未来的临床方法提供了一个有趣的概述。
期刊介绍:
The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.