Liposarcoma mixoide: características por resonancia magnética con correlación histológica

IF 1.1 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING RADIOLOGIA Pub Date : 2023-10-01 DOI:10.1016/j.rx.2021.01.005

V.M. Encinas Tobajas , C. Almeida González , D. Marcilla , M. Vallejo , A. Cano Rodríguez , J.I. Reina Sánchez de Movellán , J.M. Morales Pérez

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Abstract

Background and aims

Myxoid liposarcoma is classified in the group of sarcomas with adipose differentiation, which is the second most common group of sarcomas. However, myxoid liposarcoma is not a homogeneous entity, because the behavior and clinical course of these tumors can vary widely. This study aimed to describe the magnetic resonance imaging (MRI) features of myxoid liposarcomas and to determine whether the MRI features are associated with the histologic grade and can differentiate between low-grade and high-grade tumors and thus help in clinical decision making.

Material and methods

We studied 36 patients with myxoid liposarcomas treated at our center between 2010 and 2018. We analyzed clinical variables (age, sex, and tumor site) and MRI features (size, depth, borders, fatty component, myxoid component, non-fatty / non-myxoid component, apparent diffusion coefficient (ADC), and type of enhancement after the administration of intravenous contrast material). We correlated the MRI features with the histologic grade and the percentage of round cells.

Results

In our series, patients with myxoid liposarcomas were mainly young adults (median age, 43 years). There were no differences between sexes; 97.2% were located in the lower limbs, 86.1% were deep, and 77.8% had well-defined borders. Of the 23 myxoid liposarcomas that contained no fat, 16 (69.6%) were high grade (p = 0.01). All the tumors with a myxoid component of less than 25% were high grade (p = 0.01); 83.3% of those with a non-fatty / non-myxoid component greater than 50% were high grade (p = 0.03) and 61.5% had more than 5% round cells (p = 0.01). Diffusion sequences were obtained in 14 of the 36 patients; ADC values were high (median, 2 x 10^-3 mm²/s), although there were no significant associations between low-grade and high-grade tumors. Contrast-enhanced images were available for 30 (83.3%) patients; 83.3% of the tumors with heterogeneous enhancement were high grade (p = 0.01).

Conclusions

MRI can be useful for differentiating between high- and low-grade myxoid liposarcomas and can help in clinical decision making.

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黏液样脂肪肉瘤：磁共振特征与组织学相关性

背景与目的黏液样脂肪肉瘤属于脂肪分化型肉瘤，是第二常见的肉瘤。然而，黏液样脂肪肉瘤并不是一个单一的实体，因为这些肿瘤的行为和临床过程可能有很大的差异。本研究旨在描述黏液样脂肪肉瘤的磁共振成像（MRI）特征，并确定MRI特征是否与组织学分级有关，是否可以区分低级别和高级别肿瘤，从而有助于临床决策。材料和方法我们研究了2010年至2018年间在我们中心接受治疗的36例黏液样脂肪肉瘤患者。我们分析了临床变量（年龄、性别和肿瘤部位）和MRI特征（大小、深度、边界、脂肪成分、黏液成分、非脂肪/非黏液成分、表观扩散系数（ADC）和静脉注射造影剂后的增强类型）。我们将MRI特征与组织学分级和圆形细胞百分比相关联。结果在我们的系列中，黏液样脂肪肉瘤患者主要是年轻人（中位年龄43岁）。性别之间没有差异；97.2%位于下肢，86.1%位于深部，77.8%边界清晰。在23例不含脂肪的黏液样脂肪肉瘤中，16例（69.6%）为高级别（p＝0.01）。黏液样成分低于25%的肿瘤均为高级别肿瘤（p＝0.01%）；非脂肪/非黏液成分大于50%的患者中，83.3%为高级别（p=0.03），61.5%为圆形细胞（p=0.01）。36例患者中有14例获得了扩散序列；ADC值较高（中位数为2 x 10-3 mm2/s），尽管低级别和高级别肿瘤之间没有显著关联。30例（83.3%）患者可获得对比度增强图像；83.3%的肿瘤为高级别（p＝0.01）。结论mri有助于区分高级别和低级别黏液样脂肪肉瘤，并有助于临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

RADIOLOGIA RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.60

自引率

7.70%

发文量

105

审稿时长

52 days

期刊介绍： La mejor revista para conocer de primera mano los originales más relevantes en la especialidad y las revisiones, casos y notas clínicas de mayor interés profesional. Además es la Publicación Oficial de la Sociedad Española de Radiología Médica.