On the behavior of prolate spheroids in a standing surface acoustic wave field

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2023-10-21 DOI:10.1007/s10404-023-02690-z
Sebastian Sachs, Hagen Schmidt, Christian Cierpka, Jörg König
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Abstract

The active manipulation of particle and cell trajectories in fluids by high-frequency standing surface acoustic waves (sSAW) allows to separate particles and cells systematically depending on their size and acoustic contrast. However, process technologies and biomedical applications usually operate with non-spherical particles, for which the prediction of acoustic forces is highly challenging and remains a subject of ongoing research. In this study, the dynamical behavior of prolate spheroids exposed to a three-dimensional acoustic field with multiple pressure nodes along the channel width is examined. Optical measurements reveal an alignment of the particles orthogonal to the pressure nodes of the sSAW, which has not been reported in literature so far. The dynamical behavior of the particles is analyzed under controlled initial conditions for various motion patterns by imposing a phase shift on the sSAW. To gain detailed understanding of the particle dynamics, a three-dimensional numerical model is developed to predict the acoustic force and torque acting on a prolate spheroid. Considering the acoustically induced streaming around the particle, the numerical results are in excellent agreement with experimental findings. Using the proposed numerical model, a dependence of the acoustic force on the particle shape is found in relation to the acoustic impedance of the channel ceiling. Hence, the numerical model presented herein promises high progress for the design of separation devices utilizing sSAW, exploiting an additional separation criterion based on the particle shape.

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长椭球体在驻波场中的行为
通过高频驻波(sSAW)对流体中粒子和细胞轨迹的主动操纵,可以根据粒子和细胞的大小和声学对比度系统地分离粒子和细胞。然而,工艺技术和生物医学应用通常使用非球形颗粒,对其声学力的预测极具挑战性,并且仍然是正在进行的研究的主题。在本研究中,研究了长椭球体在沿通道宽度具有多个压力节点的三维声场中的动力学行为。光学测量揭示了粒子与sSAW的压力节点正交的排列,这在迄今为止的文献中尚未报道。通过对sSAW施加相移,分析了在受控的初始条件下各种运动模式下粒子的动力学行为。为了获得对粒子动力学的详细理解,建立了一个三维数值模型来预测作用在椭球上的声学力和力矩。考虑到颗粒周围的声学诱导流动,数值结果与实验结果非常一致。使用所提出的数值模型,发现了声力对颗粒形状的依赖性与通道顶部的声阻抗有关。因此,本文提出的数值模型有望在利用sSAW的分离装置设计方面取得巨大进展,利用了基于颗粒形状的额外分离标准。
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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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