T. N. Pashirova, Z. M. Shaikhutdinova, V. F. Mironov, A. V. Bogdanov
{"title":"Ammonium Amphiphiles Based on Natural Compounds: Design, Synthesis, Properties, and Biomedical Applications. A Review","authors":"T. N. Pashirova, Z. M. Shaikhutdinova, V. F. Mironov, A. V. Bogdanov","doi":"10.1134/S0012500823700179","DOIUrl":null,"url":null,"abstract":"<p>In order to search for new antibacterial and anticancer agents, the data of amphiphilic quaternary ammonium compounds (QAC) based on natural structures were analyzed and systematized over the past three years in this review. The analysis of publication is considered on the properties of QAS based on heterocyclic and pyridine alkaloids, alkylated phenols, terpenoids and steroids. The relationships between the structure of ammonium salts and their supramolecular self-assembly, biological activity, and cytotoxicity were tried to be revealed. In terms of synthetic ease of chemical modification, availability, biorelevance, and efficacy against strains of bacterial pathogens and antitumor activity, prospects for using natural platforms for extended trials have been identified.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"509 1","pages":"71 - 88"},"PeriodicalIF":0.8000,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Doklady Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0012500823700179","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 1
Abstract
In order to search for new antibacterial and anticancer agents, the data of amphiphilic quaternary ammonium compounds (QAC) based on natural structures were analyzed and systematized over the past three years in this review. The analysis of publication is considered on the properties of QAS based on heterocyclic and pyridine alkaloids, alkylated phenols, terpenoids and steroids. The relationships between the structure of ammonium salts and their supramolecular self-assembly, biological activity, and cytotoxicity were tried to be revealed. In terms of synthetic ease of chemical modification, availability, biorelevance, and efficacy against strains of bacterial pathogens and antitumor activity, prospects for using natural platforms for extended trials have been identified.
期刊介绍：
Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
