{"title":"The Effect of Perfluorocarbon Nanoparticles on Blood As a Cellular System","authors":"I. N. Kuznetsova, A. Yu. Lyanguzov","doi":"10.1134/S1990747823010051","DOIUrl":null,"url":null,"abstract":"<div><div><h3>\n <b>Abstract</b>—</h3><p>The effect of perfluorocarbon (PFC) nanoparticles on the functioning of blood cells is considered. Evidence is presented indicating that emulsified PFC nanoparticles in small volumes affect gas transport function of blood, increasing the rate of oxygen diffusion from erythrocytes to tissues. It was found that PFC nanoparticles also affect the state of blood cells (erythrocytes, leukocytes, and platelets) in a dose-dependent manner. It was assumed that depending on the emulsion dose, that is, the density of nanoparticles in the surrounding space of cells, the reaction of receptor apparatus can cause activation or deterioration of their functioning.</p></div></div>","PeriodicalId":484,"journal":{"name":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","volume":"17 1","pages":"20 - 27"},"PeriodicalIF":1.1000,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","FirstCategoryId":"2","ListUrlMain":"https://link.springer.com/article/10.1134/S1990747823010051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract—
The effect of perfluorocarbon (PFC) nanoparticles on the functioning of blood cells is considered. Evidence is presented indicating that emulsified PFC nanoparticles in small volumes affect gas transport function of blood, increasing the rate of oxygen diffusion from erythrocytes to tissues. It was found that PFC nanoparticles also affect the state of blood cells (erythrocytes, leukocytes, and platelets) in a dose-dependent manner. It was assumed that depending on the emulsion dose, that is, the density of nanoparticles in the surrounding space of cells, the reaction of receptor apparatus can cause activation or deterioration of their functioning.
期刊介绍：
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.
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