{"title":"Structure Determination of Antibodies and Antibody-Antigen Complexes by Molecular Replacement","authors":"Brünger Axel T.","doi":"10.1006/immu.1993.1052","DOIUrl":null,"url":null,"abstract":"<div><p>Three-dimensional structures of antibody and antibody-antigen complexes that have been solved to date exhibit highly conserved folding motifs, and the main structural differences between antibodies are restricted to the interdomain angles and the antigen-binding site. This knowledge has been successfully used to solve a large number of crystal structures of antibody fragments by molecular replacement. This paper reviews approaches that have been used in solving these crystal structures.</p></div>","PeriodicalId":79341,"journal":{"name":"ImmunoMethods","volume":"3 3","pages":"Pages 180-190"},"PeriodicalIF":0.0000,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/immu.1993.1052","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ImmunoMethods","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1058668783710521","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
Three-dimensional structures of antibody and antibody-antigen complexes that have been solved to date exhibit highly conserved folding motifs, and the main structural differences between antibodies are restricted to the interdomain angles and the antigen-binding site. This knowledge has been successfully used to solve a large number of crystal structures of antibody fragments by molecular replacement. This paper reviews approaches that have been used in solving these crystal structures.
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