Analysis of some risk factors of coronary and valvular calcification in peritoneal dialysis

Dialysis & Transplantation Pub Date : 2011-03-08 DOI:10.1002/dat.20547

Lucyna Janicka MD, PhD, Dariusz Duma MD, PhD, Agnieszka M. Grzebalska MD, PhD, Elzbieta Czekajska-Chehab MD, PhD, Andrzej Drop MD, PhD, Grzegorz Staskiewicz MD, PhD, Krzysztof Janicki MD, PhD, Janusz Solski MD, PhD, Andrzej Książek MD, PhD

{"title":"Analysis of some risk factors of coronary and valvular calcification in peritoneal dialysis","authors":"Lucyna Janicka MD, PhD, Dariusz Duma MD, PhD, Agnieszka M. Grzebalska MD, PhD, Elzbieta Czekajska-Chehab MD, PhD, Andrzej Drop MD, PhD, Grzegorz Staskiewicz MD, PhD, Krzysztof Janicki MD, PhD, Janusz Solski MD, PhD, Andrzej Książek MD, PhD","doi":"10.1002/dat.20547","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> OBJECTIVE</h3>\n \n <p>Our study was performed to analyze risk factors for coronary artery calcification (CAC) and valvular calcification (VC) in peritoneally dialyzed patients, as well as the frequency of fatal cardiovascular complications.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>The study was performed on 102 peritoneal dialyzed patients (mean time of dialysis: 37.3 ± 23 months). Patients were divided depending on the severity of calcification into three groups: A, lack of calcification; B, CAC up to 400 mm<sup>3</sup>; and C, CAC >400 mm<sup>3</sup>. CAC and VC were measured by means of computed tomography. The following risk factors for CAC and VC were analyzed: age, gender, time of peritoneal dialysis, and levels of calcium, phosphates, calcium × phosphorus product (Ca × P), C-reactive protein (CRP), fibrinogen, fetuin-A, and parathormone (PTH).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Positive correlation was found between CAC and VC expressed by Agatston and volumetric score, and serum levels of CRP and fibrinogen and patient age. In patients with CAC and VC, serum levels of phosphorus and Ca × P were significantly higher; however, such significance was not observed in patients with CAC only. Serum fetuin-A was decreased in all study groups, and was significantly lower in patients with CAC and VC than in patients with CAC only. Cardiovascular complications were significantly more frequent and mortality was higher in group C than in groups A and B.</p>\n </section>\n \n <section>\n \n <h3> CONCLUSIONS</h3>\n \n <p>In peritoneally dialyzed patients, CAC accompanied by VC is a high risk factor for mortality resulting from cardiovascular complications.</p>\n </section>\n </div>","PeriodicalId":51012,"journal":{"name":"Dialysis & Transplantation","volume":"40 3","pages":"118-122"},"PeriodicalIF":0.0000,"publicationDate":"2011-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/dat.20547","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dialysis & Transplantation","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dat.20547","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

Abstract

OBJECTIVE

Our study was performed to analyze risk factors for coronary artery calcification (CAC) and valvular calcification (VC) in peritoneally dialyzed patients, as well as the frequency of fatal cardiovascular complications.

METHODS

The study was performed on 102 peritoneal dialyzed patients (mean time of dialysis: 37.3 ± 23 months). Patients were divided depending on the severity of calcification into three groups: A, lack of calcification; B, CAC up to 400 mm³; and C, CAC >400 mm³. CAC and VC were measured by means of computed tomography. The following risk factors for CAC and VC were analyzed: age, gender, time of peritoneal dialysis, and levels of calcium, phosphates, calcium × phosphorus product (Ca × P), C-reactive protein (CRP), fibrinogen, fetuin-A, and parathormone (PTH).

RESULTS

Positive correlation was found between CAC and VC expressed by Agatston and volumetric score, and serum levels of CRP and fibrinogen and patient age. In patients with CAC and VC, serum levels of phosphorus and Ca × P were significantly higher; however, such significance was not observed in patients with CAC only. Serum fetuin-A was decreased in all study groups, and was significantly lower in patients with CAC and VC than in patients with CAC only. Cardiovascular complications were significantly more frequent and mortality was higher in group C than in groups A and B.

CONCLUSIONS

In peritoneally dialyzed patients, CAC accompanied by VC is a high risk factor for mortality resulting from cardiovascular complications.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

腹膜透析中冠状动脉和瓣膜钙化的危险因素分析

目的分析腹膜透析患者冠状动脉钙化(CAC)和瓣膜钙化(VC)的危险因素及致死性心血管并发症的发生频率。方法对102例腹膜透析患者(平均透析时间:37.3±23个月)进行研究。根据钙化的严重程度将患者分为三组:A组，缺乏钙化;B、CAC可达400mm3;C, CAC >400 mm3。通过计算机断层扫描测量CAC和VC。分析CAC和VC的危险因素:年龄、性别、腹膜透析时间、钙、磷酸盐、钙×磷产物(Ca × P)、c反应蛋白(CRP)、纤维蛋白原、胎儿素a、甲状旁腺激素(PTH)水平。结果CAC、VC的Agatston表达与容积评分呈正相关，血清CRP、纤维蛋白原水平与患者年龄呈正相关。CAC和VC患者血清磷、钙×磷水平显著升高;然而，仅在CAC患者中没有观察到这种意义。在所有研究组中，血清胎蛋白a均降低，且合并CAC和VC的患者血清胎蛋白a明显低于仅合并CAC的患者。C组心血管并发症发生率明显高于A、b组，死亡率明显高于A、b组。结论腹膜透析患者CAC合并VC是心血管并发症死亡的高危因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Dialysis & Transplantation 医学-工程：生物医学

自引率

0.00%

发文量

期刊最新文献

Extensive vascular calcification in diabetic uremic patient A product of medical advancements Dialysis care: Three decades later Persistent hypophosphathemia recovered with cinacalcet in a late renal transplanted patient How the latest evidence from clinical research informs patient care