A multi-asperity adhesive contact model for catheter and vascular artery contact in endovascular surgery

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL Biomedical Microdevices Pub Date : 2023-01-31 DOI:10.1007/s10544-023-00646-2

Yang Xu, Sundeep Mangla, Paul Gschneidner, Yong Shi

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Abstract

Contact behaviors of medical devices, such as guidewires and catheters, are critical in endovascular surgeries. In this work, a new method to predict adhesive contact force between catheter and vascular artery is presented. Multi-asperity adhesion on the surface of vascular artery, deformation of asperity and deformation of vascular substrate are all considered. The single asperity behavior is described with Johnson-Kendall-Roberts (JKR) contact model. The multi-asperity behavior is based on Greenwood–Williamson (GW) asperity model. Vascular substrate is considered as elastic bulk substrate and its deformation is determined with Hertzian pressure from asperity on a circular region on the elastic half space. The model shows that the deformation of vascular substrate accounts for the majority of the total contact deformation and significantly affects the predicted contact force. The model is verified with published experimental data. The comparison shows that the model produces very accurate prediction of contact force between catheter and vascular artery when the contact force is compressive. Parametric analysis based on asperity topography is carried out. The analysis shows that the diameter of the circular region of the interface between asperity and vascular substrate has more significant effect on the estimation of contact force than the radius of asperity. Further validation of prediction accuracy of the model under experiment is needed.

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一种用于血管内手术中导管与血管动脉接触的多粗糙度黏附接触模型

导丝、导管等医疗器械的接触行为在血管内手术中起着至关重要的作用。本文提出了一种预测导管与血管间黏附接触力的新方法。考虑了血管动脉表面多粗糙体的粘附、粗糙体的变形和血管基质的变形。用Johnson-Kendall-Roberts (JKR)接触模型描述了单粗糙性行为。多粗糙体行为基于Greenwood-Williamson (GW)粗糙体模型。将维管基底视为弹性体基底，其变形由弹性半空间上圆形区域上的凹凸不平所产生的赫兹压力决定。该模型表明，维管基底的变形占接触总变形的大部分，并对预测的接触力有显著影响。用已发表的实验数据对模型进行了验证。对比结果表明，当接触力为压缩时，该模型能较准确地预测导管与血管之间的接触力。基于粗糙地形进行了参数化分析。分析表明，相对于粗糙体半径，粗糙体与维管基体界面的圆形区域直径对接触力的估计影响更为显著。该模型的预测精度有待实验进一步验证。

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.