The role of chemical engineering in biotechnology

Colin Webb, Bernard Atkinson
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引用次数: 12

Abstract

Depending on which definition is chosen, biotechnology can be considered to be one of the oldest industrial technologies or one of the newest. For the chemical engineer, however, the major distinction is in terms of the scale of operation. The majority of products of the new biotechnology are extremely high value, low volume biochemicals. Thus recovery (separation) processes for such products may be relatively costly and energy intensive, because of the small quantities involved, but at the same time must be highly efficient in order to minimize loss of valuable product. This contrasts with the more traditional biotechnological processes of the food and beverage industries, antibiotic and medium value pharmaceuticals production, and wastewater treatment. Here, the problems for the chemical engineer are more like those in the chemical or process industries.

In this paper a typical biological process is compared with its counterpart chemical process and the role of the chemical engineer in designing and developing such a process is examined through a series of examples. Just as the chemical industry for decades was dominated by the chemist, so the bioprocess industry is still dominated by the industrial microbiologist. There are consequently many areas in which improvements can be made to established industrial biological processes by the application of simple engineering concepts.

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化学工程在生物技术中的作用
根据选择的定义,生物技术可以被认为是最古老的工业技术之一,也可以被认为是最新的工业技术之一。然而,对于化学工程师来说,主要的区别在于操作的规模。新生物技术的大部分产品都是极高价值、小批量的生物化学品。因此,这些产品的回收(分离)过程可能相对昂贵和能源密集,因为所涉及的数量很少,但同时必须高效,以尽量减少有价值产品的损失。这与食品和饮料工业、抗生素和中等价值药品生产以及废水处理等更传统的生物技术过程形成对比。在这里,化学工程师面临的问题更像化学或加工工业中的问题。本文将一个典型的生物过程与其对应的化学过程进行了比较,并通过一系列实例探讨了化学工程师在设计和开发生物过程中的作用。正如化学工业几十年来由化学家主导一样,生物加工工业仍然由工业微生物学家主导。因此,在许多领域,可以通过应用简单的工程概念来改进已建立的工业生物过程。
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