{"title":"Anti-inflammatory Dimeric Tetrahydroxanthones from an Endophytic Muyocopron laterale","authors":"Hai-Yan Cao, Cheng Yi, Sen-Feng Sun, Yong Li*, Yun-Bao Liu*","doi":"10.1021/acs.jnatprod.1c00878","DOIUrl":null,"url":null,"abstract":"<p >Twelve new dimeric tetrahydroxanthones, muyocoxanthones A–L (<b>1</b>–<b>12</b>), were isolated from the endophytic fungus, <i>Muyocopron laterale</i>. Their structures were characterized on the basis of the interpretation of NMR and HRESIMS data. The absolute configurations of <b>1</b>–<b>10</b> and <b>12</b> were unambiguously determined by ECD spectrum data and single-crystal X-ray diffraction analysis. Compounds <b>2</b>, <b>6</b>, and <b>11</b> showed inhibitory activity against the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC<sub>50</sub> values of 5.2, 1.3, and 5.1 μM, respectively.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jnatprod.1c00878","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 5
Abstract
Twelve new dimeric tetrahydroxanthones, muyocoxanthones A–L (1–12), were isolated from the endophytic fungus, Muyocopron laterale. Their structures were characterized on the basis of the interpretation of NMR and HRESIMS data. The absolute configurations of 1–10 and 12 were unambiguously determined by ECD spectrum data and single-crystal X-ray diffraction analysis. Compounds 2, 6, and 11 showed inhibitory activity against the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC50 values of 5.2, 1.3, and 5.1 μM, respectively.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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