Recuperación de la espermatogénesis tras el abuso de esteroides anabólicos androgénicos en varones. Revisión sistemática de la literatura

IF 1.2 4区医学 Q3 UROLOGY & NEPHROLOGY Actas urologicas espanolas Pub Date : 2024-03-01 DOI:10.1016/j.acuro.2023.07.001

O. Rajmil , J. Moreno-Sepulveda

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Abstract

Objective

This systematic review aims to evaluate the optimal treatment for male infertility resulting from Anabolic Androgenic Steroids (AAS) abuse.

Methods

A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies that compared different protocols for the recovery of spermatogenesis in patients after AAS use were included.

Results

13 studies investigating different protocols to restore spermatogenesis in patients with AAS abuse met the inclusion criteria. The available agents that showed restoration of spermatogenesis include injectable gonadotropins, selective estrogen receptor modulators, and aromatase inhibitors, but their use is still poorly described in the literature.

Conclusions

Clinicians need to be aware of the detrimental effects of AAS on spermatogenesis. AAS-associated infertility may be reversible, but sperm production may take over a year to normalize. Both conservative and aggressive treatment can boost spermatogenesis with positive results. Further understanding of male reproductive endocrinology and high-quality data on the field of restoration of spermatogenesis after AAS abuse are warranted.

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男性滥用同化雄性类固醇后精子发生的恢复。系统文献综述

目的本系统综述旨在评估合成代谢雄性类固醇（AAS）滥用导致的男性不育症的最佳治疗方法。方法根据系统综述和元分析首选报告项目（PRISMA）声明进行了系统综述。结果有 13 项研究符合纳入标准，这些研究调查了滥用 AAS 患者恢复精子生成的不同方案。可用于恢复生精功能的药物包括注射促性腺激素、选择性雌激素受体调节剂和芳香化酶抑制剂，但这些药物的使用在文献中的描述仍然很少。AAS相关不育症可能是可逆的，但精子生成可能需要一年多的时间才能恢复正常。保守治疗和积极治疗都能促进精子生成，并取得积极效果。我们有必要进一步了解男性生殖内分泌学，并提供滥用 AAS 后精子生成恢复方面的高质量数据。

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来源期刊

Actas urologicas espanolas UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

46 days

期刊介绍： Actas Urológicas Españolas is an international journal dedicated to urological diseases and renal transplant. It has been the official publication of the Spanish Urology Association since 1974 and of the American Urology Confederation since 2008. Its articles cover all aspects related to urology. Actas Urológicas Españolas, governed by the peer review system (double blinded), is published online in Spanish and English. Consequently, manuscripts may be sent in Spanish or English and bidirectional free cost translation will be provided.