Tomasz Mikolajczyk , Claudine Weil , Bernard Breton
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引用次数: 5
Abstract
1. Perifusion of dispersed pituitary cells and pituitary cell culture was used to investigate the effects of cholinergic drugs on the secretion of maturational gonadotropin (GtH2) in carp.
2. Nicotine strongly, and in a dose dependent manner, stimulated GtH2 release in male and in female carp (from 10−8M in the Perifusion and 10−10M in the cells cultures).
3. Nicotine is 10 times more active in females than in males.
4. The results suggest that in carp, nicotine stimulates GtH2 release directly from the pituitary cells, indicating a possible involvement of a cholinergic system in the regulation of GtH2 secretion in teleost fish.
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