Spontaneous regression of malignant pleural mesothelioma: A case report

Cancer treatment communications Pub Date : 2015-01-01 DOI:10.1016/j.ctrc.2015.02.002

Jacques Raphael , Michelle Lui , Laura Jimenez-Juan , Suneil Khanna , Sunil Verma

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引用次数: 1

Abstract

Malignant pleural mesothelioma (MPM) is a rare pleural disease with a poor prognosis. Currently treatment options are limited and the outcome is generally quite poor.

We report the case of a 76-year-old man diagnosed with locally advanced MPM who had partial spontaneous response for 2 years and remained asymptomatic for more than 3 years. The patient was taking specific herbal and vegetable diet during the course of response.

In our review of literature, a number of prognostic factors predict for better survival and response. However our patients did not have any of these factors. There have been reports of immune-induced responses in the literature. Our patient did indeed use some herbal products that might interfere with the immune system and explain his tumour regression and long period of disease stability. Further analyses and studies are needed in this setting to explore and identify specific immune pathways and targets to develop more effective treatment for MPM.

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恶性胸膜间皮瘤自发性消退1例

恶性胸膜间皮瘤是一种少见的胸膜疾病，预后较差。目前的治疗选择有限，结果通常很差。我们报告一个76岁的男性诊断为局部晚期MPM的病例，他有部分自发反应2年，无症状持续3年以上。在缓解过程中，患者服用特定的草药和蔬菜饮食。在我们的文献回顾中，一些预后因素可以预测更好的生存和反应。然而，我们的病人没有这些因素。文献中已有免疫诱导反应的报道。我们的病人确实使用了一些可能干扰免疫系统的草药产品，这解释了他的肿瘤消退和长时间的疾病稳定。在这种情况下，需要进一步的分析和研究来探索和确定特定的免疫途径和靶点，以开发更有效的治疗MPM的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cancer treatment communications

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