Vitamin D receptor gene rs4334089 polymorphism and Parkinson’s disease in Iranian population

Basal ganglia Pub Date : 2016-08-01 DOI:10.1016/j.baga.2016.04.001

Atena Fazeli , Marzieh Motallebi , Javad Jamshidi , Abolfazl Movafagh , Hamid Ghaedi , Babak Emamalizadeh , Kaveh Kashani , Hossein Darvish

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引用次数: 5

Abstract

Parkinson disease (PD) is a neurodegenerative disorder with both contributions of genetic and environmental factors. Protective functions of vitamin D and then vitamin D receptor (VDR) in PD have been declared recently. In this study we investigated the association of VDR rs4334089 gene polymorphism with PD in Iranian population.

A total of 1040 subjects including 520 PD patients and 520 unrelated control subjects were recruited in a case-control study. DNA was extracted from peripheral blood of all subjects and rs4334089 polymorphism of VDR was genotyped using PCR-RFLP method.

Genotype and allele frequency of rs4334089 were significantly different in PD and control groups and A allele was significantly more frequent in PD patients compared to control group. Our findings suggest that VDR rs4334089 A allele could be a risk factors for PD in Iranian population, although more replication studies are needed to confirm our findings.

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伊朗人群维生素D受体基因rs4334089多态性与帕金森病

帕金森病(PD)是一种遗传和环境因素共同作用的神经退行性疾病。维生素D和维生素D受体(VDR)对帕金森病的保护作用是近年来研究的重点。在这项研究中，我们研究了VDR rs4334089基因多态性与伊朗人群PD的关系。在病例对照研究中，共招募了1040名受试者，其中包括520名PD患者和520名不相关的对照组。从所有受试者的外周血中提取DNA，采用PCR-RFLP方法对VDR rs4334089多态性进行基因分型。PD组与对照组rs4334089基因型及等位基因频率差异有统计学意义，且PD患者中A等位基因频率明显高于对照组。我们的研究结果表明，VDR rs4334089 A等位基因可能是伊朗人群PD的危险因素，尽管需要更多的复制研究来证实我们的发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Basal ganglia

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