Investigations on artificially extending the spectral range of natural vision.

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL APL Bioengineering Pub Date : 2023-10-24 eCollection Date: 2023-12-01 DOI:10.1063/5.0156463
Abhijith Krishnan, C S Deepak, K S Narayan
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Abstract

Organic semiconductors are being explored as retinal prosthetics with the prime attributes of bio-compatibility and conformability for seamless integration with the retina. These polymer-based artificial photoreceptor films are self-powered with light-induced signal strength sufficient to elicit neuronal firing events. The molecular aspect of these semiconductors provides wide spectral tunability. Here, we present results from a bulk heterostructure semiconductor blend with a wide spectral response range. This combination elicits clear spiking activity from a developing blind-chick embryonic retina in the subretinal configuration in response to white light. The response is largely triggered by the blue-green spectral regime rather than the red-NIR regime for the present polymer semiconductor layer attributes.

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人工扩大自然视觉光谱范围的研究。
有机半导体作为视网膜假肢正在被探索,其主要特征是生物相容性和可与视网膜无缝集成的适应性。这些基于聚合物的人工光感受器膜是自供电的,具有足以引发神经元放电事件的光诱导信号强度。这些半导体的分子方面提供了宽光谱可调谐性。在这里,我们展示了具有宽光谱响应范围的体异质结构半导体混合物的结果。这种组合从发育中的失明小鸡胚胎视网膜中激发出明显的尖峰活性,视网膜下结构对白光的反应。对于本聚合物半导体层属性,响应主要由蓝绿色光谱区域而不是红色NIR区域触发。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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