Race, pigmentation, and the human skin barrier-considerations for dermal absorption studies.

IF 3.6 Q2 TOXICOLOGY Frontiers in toxicology Pub Date : 2023-10-11 eCollection Date: 2023-01-01 DOI:10.3389/ftox.2023.1271833
Alec T Salminen, Prashiela Manga, Luísa Camacho
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Abstract

A functional human skin barrier is critical in limiting harmful exposure to environmental agents and regulating the absorption of intentionally applied topical drug and cosmetic products. Inherent differences in the skin barrier between consumers due to extrinsic and intrinsic factors are an important consideration in the safety assessment of dermatological products. Race is a concept often used to describe a group of people who share distinct physical characteristics. The observed predisposition of specific racial groups to certain skin pathologies highlights the potential differences in skin physiology between these groups. In the context of the human skin barrier, however, the current data correlating function to race often conflict, likely as a consequence of the range of experimental approaches and controls used in the existing works. To date, a variety of methods have been developed for evaluating compound permeation through the human skin, both in vivo and in vitro. Additionally, great strides have been made in the development of reconstructed human pigmented skin models, with the flexibility to incorporate melanocytes from donors of different race and pigmentation levels. Together, the advances in the production of reconstructed human skin models and the increased adoption of in vitro methodologies show potential to aid in the standardization of dermal absorption studies for discerning racial- and skin pigmentation-dependent differences in the human skin barrier. This review analyzes the existing data on skin permeation, focusing on its interaction with race and skin pigmentation, and highlights the tools and research opportunities to better represent the diversity of the human populations in dermal absorption assessments.

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皮肤吸收研究的种族、色素沉着和人类皮肤屏障因素。
功能性人体皮肤屏障对于限制有害环境因素的暴露和调节有意使用的局部药物和化妆品的吸收至关重要。由于外在和内在因素,消费者之间皮肤屏障的内在差异是皮肤科产品安全性评估的一个重要考虑因素。种族是一个经常用来描述一群有着独特身体特征的人的概念。观察到的特定种族群体对某些皮肤病理的易感性突出了这些群体之间皮肤生理学的潜在差异。然而,在人类皮肤屏障的背景下,当前与种族相关的数据经常发生冲突,这可能是现有工作中使用的一系列实验方法和控制的结果。迄今为止,已经开发了多种方法来评估化合物在体内和体外通过人体皮肤的渗透性。此外,重建的人类色素沉着皮肤模型的开发也取得了巨大进展,可以灵活地结合来自不同种族和色素沉着水平捐赠者的黑色素细胞。总之,重建人类皮肤模型的生产进展和体外方法的日益采用,显示出有助于皮肤吸收研究标准化的潜力,以识别人类皮肤屏障中种族和皮肤色素沉着依赖性的差异。这篇综述分析了皮肤渗透的现有数据,重点关注其与种族和皮肤色素沉着的相互作用,并强调了在皮肤吸收评估中更好地代表人类多样性的工具和研究机会。
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3.80
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审稿时长
13 weeks
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