HLA-DRB1 as a risk or resistance factor in Autoimmune Hepatitis

Inmunologia (Barcelona, Spain : 1987) Pub Date : 2011-10-01 DOI:10.1016/j.inmuno.2011.07.003

Silvia García Borrás , José Moreno , Nidia Abraham , Hugo Tanno , Marianela García Laplaca , María Celina Rossi , Liliana Racca , Amelia Racca

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引用次数: 3

Abstract

Although the pathogenesis of Autoimmune Hepatitis (AIH) is unknown, the susceptibility is determined in part by genes linked to the region of HLA class II. The study included 47 unrelated individuals with the diagnostic of type 1 AIH. A control group (n = 81) of healthy individuals was included. The alleles were tested for HLA class II genotyping using polymerase chain reaction and sequence-specific primers technique (PCR-SSP). Among patients with AIH alleles occurring at higher frequencies were DRB1*04, DRB1*03, DRB1*01, DRB1*07 and DRB1*13. With reference to controls the following alleles were the most prevalent DRB1*07, DRB1*11, DRB1*08, DRB1*13 and DRB1*01. In comparison with the control group, AIH patients revealed a greater occurrence of the DRB1*03 and DRB1*04. These alleles can be considered as predisposing factors for the development of AIH. By contrast, DRB1*08 and DRB1*11 alleles were less frequent among patients and hence could be involved in disease resistance.

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HLA-DRB1作为自身免疫性肝炎的危险或抵抗因素

尽管自身免疫性肝炎(AIH)的发病机制尚不清楚，但其易感性部分是由与HLAⅱ类区域相关的基因决定的。该研究包括47名诊断为1型AIH的无亲属个体。对照组(n = 81)为健康个体。采用聚合酶链反应和序列特异性引物技术(PCR-SSP)对等位基因进行HLAⅱ类分型检测。发生频率较高的AIH等位基因为DRB1*04、DRB1*03、DRB1*01、DRB1*07和DRB1*13。与对照相比，DRB1*07、DRB1*11、DRB1*08、DRB1*13和DRB1*01等位基因最为普遍。与对照组相比，AIH患者DRB1*03和DRB1*04的发生率更高。这些等位基因可被认为是AIH发展的易感因素。相比之下，DRB1*08和DRB1*11等位基因在患者中较少出现，因此可能参与了疾病抵抗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inmunologia (Barcelona, Spain : 1987)

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