Association of reelin gene (RELN) polymorphism with autism spectrum disorder in the Bangladeshi population

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2021-09-01 DOI:10.1016/j.mgene.2021.100901

Shahriar Ahmed , Ahmed Rakib , Mir Muhammad Nasir Uddin , Mohammad Safiqul Islam , S.M. Amanat Ullah , Talha Bin Emran

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引用次数: 1

Abstract

Purpose

This study was conducted to detect the two single-nucleotide polymorphisms (SNPs) (g.333509A > C and g.504742G > A) of the reelin (RELN) gene and to detect their association with autism spectrum disorder (ASD) in the Bangladeshi population.

Methods and materials

Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing were performed to identify the SNPs, and their association with ASD was evaluated in a total of 216 Bangladeshi people, which included 108 autistic patients and 108 healthy participants.

Results

The alleles and genotype frequencies of g.333509A > C and g.504742G > A showed no significant relationship with ASD (χ² = 0.603; p = 0.479 and χ² = 0.274; p = 0.601, respectively).

Conclusions

Our findings indicate that these two variants of the RELN gene do not seem to be related with ASD in the Bangladeshi population. Therefore, further studies are suggested for identifying the SNPs of the RELN gene responsible for ASD in the Bangladeshi population.

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reelin基因(RELN)多态性与孟加拉国人群自闭症谱系障碍的关联

目的检测两种单核苷酸多态性(g.333509A >C和g.504742G >A) reelin (RELN)基因，并检测其与孟加拉国人群中自闭症谱系障碍(ASD)的关系。方法和材料采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)和DNA测序方法鉴定snp，并在216名孟加拉国人(包括108名自闭症患者和108名健康参与者)中评估其与ASD的相关性。结果g.333509A >的等位基因及基因型频率;C和g.504742G >A与ASD无显著相关(χ2 = 0.603;P = 0.479， χ2 = 0.274;P = 0.601)。结论我们的研究结果表明，这两种RELN基因变体似乎与孟加拉国人群的ASD无关。因此，建议进一步研究确定孟加拉国人群中与ASD有关的RELN基因的snp。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.