Reduction of Newcastle Disease Vaccine Dose Using a Novel Adjuvant for Cellular Immune Response in Poultry

Abstract

Water-in-mineral oil adjuvants induce a strong long-term humoral immune response and are widely used in poultry vaccines. New adjuvants that also increase the cellular immune response could help to extend the vaccinal cross- protection against different viral strains or serotypes. We have developed a new water-in-oil adjuvant, Montanide^TM ISA 71 VG, based on a specific enriched light mineral oil which stimulates both humoral and cellular immune responses. Here, using a Newcastle Disease vaccine model, we demonstrate that this new adjuvant is safe, can improve vaccine efficacy in poultry and could allow the reduction of injection doses of inactivated poultry vaccines.