{"title":"β-Lactam antibiotics, β-lactamases and bacterial resistance","authors":"L.P. Kotra, S. Mobashery","doi":"10.1016/S0020-2452(98)80009-2","DOIUrl":null,"url":null,"abstract":"<div><p>β-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of β-lactam drugs, of which the catalytic function of β-lactamase is the most important. These enzymes catalyse hydrolysis of β-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clinical implications.</p></div>","PeriodicalId":89103,"journal":{"name":"Bulletin de l'Institut Pasteur","volume":"96 3","pages":"Pages 139-150"},"PeriodicalIF":0.0000,"publicationDate":"1998-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0020-2452(98)80009-2","citationCount":"51","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin de l'Institut Pasteur","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020245298800092","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 51
Abstract
β-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of β-lactam drugs, of which the catalytic function of β-lactamase is the most important. These enzymes catalyse hydrolysis of β-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clinical implications.
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