{"title":"Bryn Bridges and mutagenesis: exploring the intellectual space","authors":"Graham C. Walker","doi":"10.1016/S0921-8777(00)00075-6","DOIUrl":null,"url":null,"abstract":"<div><p>The products of the SOS-regulated <em>umuDC</em><span> genes are required for most UV and chemical mutagenesis in </span><em>Escherichia</em> <em>coli</em>. Recently it has been recognized that UmuC is the founding member of a superfamily of novel DNA polymerases found in all three kingdoms of life. Key findings leading to these insights are reviewed, placing a particular emphasis on contributions made by Bryn Bridges and on his interest in the importance of interactions between the <em>umuDC</em> gene products and the replicative DNA polymerase.</p></div>","PeriodicalId":100935,"journal":{"name":"Mutation Research/DNA Repair","volume":"485 1","pages":"Pages 69-81"},"PeriodicalIF":0.0000,"publicationDate":"2001-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0921-8777(00)00075-6","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/DNA Repair","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0921877700000756","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
The products of the SOS-regulated umuDC genes are required for most UV and chemical mutagenesis in Escherichiacoli. Recently it has been recognized that UmuC is the founding member of a superfamily of novel DNA polymerases found in all three kingdoms of life. Key findings leading to these insights are reviewed, placing a particular emphasis on contributions made by Bryn Bridges and on his interest in the importance of interactions between the umuDC gene products and the replicative DNA polymerase.
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