Yu-feng LI , Qing-min BU , Yi QIAN , Yi PAN , Jian-xin LI , Le-qun HUANG , Hong-jun ZHU
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引用次数: 1
Abstract
Several borohydride reagents: sodium borohydride, sodium cyanoborohydride, soudium acetoxyborohydride and soudium triacetoxyborohydride were screened, respectively, for the reduction of 7-demethylsinomenine, which was an α,β-dicarbonyl compound derived from sinomenine. Highly regio- and stereo-selectivity was acquired when sodium cyanoborohydride or NaBH(OAc)3 was used. The product was structurally confirmed as 7R configuration by NMR, X-ray crystal diffraction analysis. Some preliminary discussion was also made on the mechanism of the selective reduction.
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