{"title":"Cation Requirement of Natural, In-Vitro Generated and Antibody Dependent Killing Exerted by Human Lymphocytes","authors":"S. Argov, A. Poros, E. Klein","doi":"10.1016/S0340-904X(79)80058-5","DOIUrl":null,"url":null,"abstract":"<div><p>Three cytotoxic systems, NK, ADCC and the seemingly indiscriminative cytotoxiciry of in vitro activated lymphocytes (cultivated with K 562) were found to require Ca++ and did not function in Mg<sup>+ +</sup>. The optimum concentration of Ca<sup>+ +</sup> was identical for the three systems and for various lymphocyte subsets.</p><p>15 minutes after initiation of the interaction cell damage had already occurred in all three systems.</p></div>","PeriodicalId":101288,"journal":{"name":"Zeitschrift für Immunit?tsforschung: Immunobiology","volume":"156 1","pages":"Pages 25-34"},"PeriodicalIF":0.0000,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(79)80058-5","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Immunit?tsforschung: Immunobiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0340904X79800585","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
Three cytotoxic systems, NK, ADCC and the seemingly indiscriminative cytotoxiciry of in vitro activated lymphocytes (cultivated with K 562) were found to require Ca++ and did not function in Mg+ +. The optimum concentration of Ca+ + was identical for the three systems and for various lymphocyte subsets.
15 minutes after initiation of the interaction cell damage had already occurred in all three systems.
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