{"title":"Diagnostic signatures from microarrays: a bioinformatics concept for personalized medicine","authors":"Rainer Spang","doi":"10.1016/S1478-5382(03)02329-1","DOIUrl":null,"url":null,"abstract":"<div><p>Microarrays can be used as diagnostic clinical tools, providing a global overview of gene transcription in diseased tissues. Expression profiles can be easily obtained in a single assay and provide exhaustive information about molecular events that are often directly linked to the cause of a disease. However, the high complexity of the data are challenging. This article reviews recent efforts in bioinformatics and statistics to overcome this problem and make feasible the clinical analysis of gene expression profiles.</p></div>","PeriodicalId":9227,"journal":{"name":"Biosilico","volume":"1 2","pages":"Pages 64-68"},"PeriodicalIF":0.0000,"publicationDate":"2003-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1478-5382(03)02329-1","citationCount":"47","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosilico","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1478538203023291","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 47
Abstract
Microarrays can be used as diagnostic clinical tools, providing a global overview of gene transcription in diseased tissues. Expression profiles can be easily obtained in a single assay and provide exhaustive information about molecular events that are often directly linked to the cause of a disease. However, the high complexity of the data are challenging. This article reviews recent efforts in bioinformatics and statistics to overcome this problem and make feasible the clinical analysis of gene expression profiles.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
