Papel de los lípidos en la ateroesclerosis

Fernando Civeira , Victoria Marco-Benedí , Ana Cenarro
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Abstract

In recent years, it has been shown that the circulating level of particles containing apolipoprotein B, especially low-density lipoproteins (LDLs) and lipoprotein(a), is not a risk factor for cardiovascular disease but is instead a major etiological factor. Indisputable evidence has come from prospective observational studies, Mendelian randomization studies, animal models of arteriosclerosis involving the manipulation of lipid-related genes, human genetic diseases (e.g. monogenic familial hypercholesterolemia and hypercholesterolemia associated with an elevated lipoprotein(a) concentration), and interventional studies with lipid-lowering agents. This article reviews these findings and summarizes current understanding of the principle pathogenic mechanisms that make LDL cholesterol one of the main causes of atherosclerotic cardiovascular disease.

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脂质在动脉粥样硬化中的作用
近年来,研究表明含有载脂蛋白B的颗粒,特别是低密度脂蛋白(ldl)和脂蛋白(a)的循环水平不是心血管疾病的危险因素,而是一个主要的病因因素。无可争议的证据来自前瞻性观察性研究、孟德尔随机化研究、涉及操纵脂类相关基因的动脉硬化动物模型、人类遗传疾病(例如单基因家族性高胆固醇血症和与脂蛋白(a)浓度升高相关的高胆固醇血症)以及使用降脂剂的干预性研究。本文综述了这些发现,并总结了目前对使LDL胆固醇成为动脉粥样硬化性心血管疾病的主要原因之一的主要致病机制的理解。
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来源期刊
Revista Espanola de Cardiologia Suplementos
Revista Espanola de Cardiologia Suplementos Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.20
自引率
0.00%
发文量
1
期刊介绍: Revista Española de Cardiología, is an international scientific journal dealing with cardiovascular medicine. Revista Española de Cardiología, the official publication of the Spanish Society of Cardiology, publishes research articles related to cardiovascular diseases. Articles are published in Spanish for the paper edition and in both Spanish and English in the electronic edition, which is available on the Internet. Regular sections include original articles reporting clinical or basic research, brief reports, review articles, editorials and letters to the Editor.
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