Ethical Conduct of Research in the Clinical Environment

Abstract

Clinical research has a long history of questionable ethical practice. Abuse of subjects and neglectful research practices have harmed individuals, groups, and the reputation of the scientific community. Policies, codes, and guidelines have been implemented and enforced as a result. To ensure ethical research practice, clinical trials and studies need to be assessed at various stages to ensure ethical design, just recruitment practices, voluntary informed consent, safe and ethical conduct, and appropriate dissemination of results. This paper identifies and explains ethical principles that apply to research. The purpose and focus of the four fundamental policy documents that inform current research practice are outlined. Ethical challenges that a researcher may face are also discussed. The requirements related to the humane use of animals for research purposes will be considered. Lastly, controversies and challenges with exporting research to developing countries will be briefly discussed.