High-dose estrogen-progestogen injections in gonadal dysgenesis, ovarian hypoplasia, and androgen insensitivity syndrome: Impact on bone density

Abstract

Osteopenia is common in gonadal dysgenesis when no sex steroid replacement therapy is carried out. Four patients with gonadal dysgenesis, one with ovarian hypoplasia, and one with androgen insensitivity syndrome, all having osteopenia, were treated by high-dose estrogen-progestogen injections (so-called “pseudopregnancy”) for 6 months. Each patient showed considerable increase in lumbar spine bone mineral density and impressive secondary sexual development during therapy.