P. Picco , L.R. Garibaldi , M. Di Rocco , E. Podesta , M. Faraci , P. Levratto , M. Gattorno , S. Pang
{"title":"In utero virilization by danazol: Effects on adrenal steroidogenesis","authors":"P. Picco , L.R. Garibaldi , M. Di Rocco , E. Podesta , M. Faraci , P. Levratto , M. Gattorno , S. Pang","doi":"10.1016/S0932-8610(19)80133-0","DOIUrl":null,"url":null,"abstract":"<div><p>The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after <em>in utero</em> exposure to danazol.</p></div>","PeriodicalId":80358,"journal":{"name":"Adolescent and pediatric gynecology","volume":"8 2","pages":"Pages 97-100"},"PeriodicalIF":0.0000,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0932-8610(19)80133-0","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Adolescent and pediatric gynecology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0932861019801330","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The measurement of serum concentrations of Δ4- and Δ5-steroid hormones after intravenous adrenocorticotropic hormone stimulation in a 4-month-old infant female pseudohermaphrodite, who had been exposed to danazol in the first 20 weeks of gestation, showed normal 17-hydroxyprogesterone and compound S (11-deoxycortisol) but elevated 17-hydroxypregnenolone. Thus, protracted postnatal inhibition of adrenal 3β-hydroxysteroid dehydrogenase activity may occur after in utero exposure to danazol.
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