Are the inhibitory and faciliatory effects during retrieval of semantically related items present in amnestic mild cognitive impairment?

IF 2 4区 心理学 Q2 PSYCHOLOGY Journal of Neuropsychology Pub Date : 2022-08-15 DOI:10.1111/jnp.12286
Laura Serra, Giulia Bechi Gabrielli, Carlotta Di Domenico, Chiara Del Bono, Camillo Marra, Leonardo Lopiano, Carlo Caltagirone, Marco Bozzali
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Abstract

Prefrontal functions subserve inhibition control for retrieval of semantically related items inducing forgetting 19 a-MCI patients and 29 controls underwent neuropsychological evaluation and retrieval-practice paradigm (RPP) to estimate baseline remember (BR), retrieval-induced facilitation (FAC) and retrieval-induced forgetting (RIF). A-MCI patients underwent also 3 T-MRI to assess relationship between regional grey matter (rGM) volumes and RPP indexes Behaviourally, RIF and FAC were both observed controls, while RIF only was observed in a-MCI patients. In patients but not in controls, RIF was associated with cognitive efficiency and FAC with memory performance. Patients showed also associations between BR and rGM volumes in the precuneus, no association was found between rGM volumes and RIF and FAC. A-MCI patients did not benefit from repeated practice during retrieval of studied items, which is likely due to their memory disorder. In contrast, patient cognitive efficiency would drive retrieval suppression of interfering stimuli.

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遗忘性轻度认知障碍患者在检索语义相关项目时是否存在抑制和促进效应?
对19例a-MCI患者和29例对照组进行了神经心理学评价和检索-实践范式(RPP),以评估基线记忆(BR)、检索诱发促进(FAC)和检索诱发遗忘(RIF)。A-MCI患者还进行了3次T-MRI检查,以评估区域灰质(rGM)体积与RPP指数之间的关系。行为上,RIF和FAC均为观察对照组,而RIF仅在A-MCI患者中观察到。在患者中,RIF与认知效率有关,FAC与记忆表现有关。患者也显示出楔前叶BR和rGM体积之间的相关性,rGM体积与RIF和FAC之间没有相关性。A-MCI患者在检索研究项目时没有从重复练习中获益,这可能是由于他们的记忆障碍。相反,患者的认知效率会驱动干扰刺激的检索抑制。
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来源期刊
Journal of Neuropsychology
Journal of Neuropsychology 医学-心理学
CiteScore
4.50
自引率
4.50%
发文量
34
审稿时长
>12 weeks
期刊介绍: The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.
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