Melanoma and subcutaneous adipose tissue: Role of peritumoral adipokines in disease characterization and prognosis

IF 3.9 3区 医学 Q2 CELL BIOLOGY Pigment Cell & Melanoma Research Pub Date : 2023-06-19 DOI:10.1111/pcmr.13103
Elisa Molinelli, Gabriele Ceccarelli, Sonia Fantone, Eleonora Di?Mercurio, Daisy Gambini, Andrea Maurizi, Jessica Perugini, Giovanni Tossetta, Valerio Brisigotti, Edoardo De?Simoni, Claudia Sapigni, Giulio Rizzetto, Anna Campanati, Oriana Simonetti, Daniela Marzioni, Annamaria Offidani
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Abstract

In the last decades, the concept of adipose organ has emerged, giving adipose tissue an active endocrine and immunologic function through the secretion of multiple cytokines and chemokines that seem to be implicated in the development and progression of several cancer, including cutaneous melanoma. In this pilot experimental study, we analyzed the expression in the peritumor subcutaneous adipose tissue of the most significant adipokines involved in the processes of carcinogenesis and metastasis in a population of melanoma patients and in two control groups composed of melanocytic nevi and epidermoid cysts, respectively. We correlated the results obtained with the main disease prognostic factors observing a statistically significant increase in the expression of PAI1, LEP, CXCL1, NAMPT, and TNF-α at the level of the peritumor tissue of the melanoma samples compared to the control groups and a correlation of the same with the histopathological prognostic factor of melanoma. Our preliminary study shows that the overexpression of PAI1, LEP, CXCL1, NAMPT, and TNF-α may contribute to the growth and to the local aggressiveness of cutaneous melanoma. It opens the hypothesis of a direct oncogenic role of subcutaneous adipose tissue and adipokines in the tumorigenesis of melanoma.

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黑色素瘤和皮下脂肪组织:瘤周脂肪因子在疾病表征和预后中的作用
在过去的几十年里,脂肪器官的概念已经出现,通过分泌多种细胞因子和趋化因子,脂肪组织具有活跃的内分泌和免疫功能,这些细胞因子和趋化因子似乎与几种癌症的发生和进展有关,包括皮肤黑色素瘤。在这项前期实验研究中,我们分析了在黑色素瘤患者群体和由黑素细胞痣和表皮样囊肿组成的两个对照组中,参与癌变和转移过程的最重要的脂肪因子在瘤周皮下脂肪组织中的表达。我们将得到的结果与主要疾病预后因素相关联,观察到与对照组相比,黑色素瘤样本瘤周组织水平上PAI1、LEP、CXCL1、NAMPT和TNF-α的表达具有统计学意义,并且与黑色素瘤的组织病理学预后因素具有相同的相关性。我们的初步研究表明,过表达的PAI1, LEP, CXCL1, NAMPT和TNF-α可能有助于皮肤黑色素瘤的生长和局部侵袭性。它开启了皮下脂肪组织和脂肪因子在黑色素瘤发生中的直接致癌作用的假设。
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来源期刊
Pigment Cell & Melanoma Research
Pigment Cell & Melanoma Research 医学-皮肤病学
CiteScore
8.90
自引率
2.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders
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