Methadone Maintenance in Older Adults: An Exploratory Study

D. Sivesind, M. Todman, Anna E. Odom, Randy M. Seewald, Ranjit Rajaratnam, D. Roane, Prameet Singh, Val Bonilla, Jeffrey Ditzell, D. Novak
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引用次数: 2

Abstract

Methadone has been used for the treatment of opioid addictions since the early nineteen-sixties. It is estimated that more than 200,000 individuals take methadone to control their opiate addiction (Blaney & Craig, 1999). Many of those individuals (~20%) have been in opioid-substitute treatment for 10 years or more (SAMHSA, 1994). A review of the literature indicates that relatively little is known about the effects of long term methadone use and its interaction with the physical, psychological and psychosocial aspects of the aging process. However, given the steady aging of the population in general and the methadone maintenance treatment (MMT) population in particular, there is a compelling need for a better understanding of the risks and benefits associated with the extended use of methadone in older adults. Beth Israel Medical Center (BIMC) has an extensive network of MMT clinics. The demographic profile of the clientele suggests that BIMC's clinics serve one of the largest populations of elderly methadone patients in the continental United States. We propose to conduct an exploratory study of BIMC's MMT population in order to document the prevalence of psychiatric, physical and psychosocial co-morbidities in the elderly members of that population (>=55 y/o). By comparing this profile with: (a) the profile of a representative sample of younger MMT patients (18-54 y/o); and (b) published prevalence data from the non-MMT, elderly population, we hope to identify areas of dysfunction and modes of adaptation that appear to be uniquely attributable to the interaction of long term methadone use and aging, and thus possible candidates for further and more extensive study.
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老年人美沙酮维持:一项探索性研究
自20世纪60年代初以来,美沙酮一直用于治疗阿片类药物成瘾。据估计,超过20万人服用美沙酮来控制他们的阿片类药物成瘾(Blaney & Craig, 1999)。其中许多人(约20%)已经接受阿片类药物替代治疗10年或更长时间(SAMHSA, 1994)。对文献的回顾表明,人们对长期使用美沙酮的影响及其与衰老过程的生理、心理和社会心理方面的相互作用知之甚少。然而,考虑到总体人口的稳定老龄化,特别是美沙酮维持治疗(MMT)人群,迫切需要更好地了解与老年人长期使用美沙酮相关的风险和益处。贝斯以色列医疗中心(BIMC)拥有广泛的MMT诊所网络。客户的人口统计资料表明,BIMC的诊所服务于美国大陆最大的老年美沙酮患者群体之一。我们建议对BIMC的MMT人群进行探索性研究,以记录该人群中老年人精神、身体和社会心理合并症的患病率(>=55 y/o)。通过将该概况与:(a)年轻MMT患者(18-54岁)的代表性样本的概况;和(b)发表的非mmt老年人群的患病率数据,我们希望确定功能障碍领域和适应模式,这些似乎是长期使用美沙酮和衰老的相互作用的唯一原因,因此可能需要进一步和更广泛的研究。
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